4-Chlor-benzolthiosulfonsaeure | 77663-66-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Chlor-benzolthiosulfonsaeure
• 英文别名: 4-chloro-benzenethiosulfonic acid；(4-Chlorophenyl)-hydroxy-oxo-sulfanylidene-lambda6-sulfane；(4-chlorophenyl)-hydroxy-oxo-sulfanylidene-λ6-sulfane
• CAS: 77663-66-2
• 化学式: C₆H₅ClO₂S₂
• 分子量: 208.69
• InChiKey: GDUXAYWBHVYCGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙醚 、 4-Chlor-benzolthiosulfonsaeure 、 2-硝基苯硫氯 生成 (4-chloro-benzenesulfonyl)-(2-nitro-phenyl)-disulfane
  参考文献：
  名称：

  Brooker; Child; Smiles, Journal of the Chemical Society, 1927, p. 1387

  摘要：

  DOI：

文献信息

• Thiosulfonic acid S-esters as agents for protecting material
  申请人：——

  公开号：US20020151570A1

  公开（公告）日：2002-10-17

  The novel and known thiosulfonic acid esters of the formula (I) 1 in which R 1 and R 2 have the meaning given in the description are highly suitable for use as biocides for protecting industrial materials. Methods for using such compositions, compositions containing such esters.

  式 (I) 的新型和已知硫代磺酸酯 1 其中 R 1 和 R 2 具有说明中给出的含义，非常适合用作保护工业材料的杀菌剂。使用此类组合物的方法、含有此类酯的组合物。
• CHIRAL CONTROL
  申请人：WAVE LIFE SCIENCES LTD.

  公开号：US20210130821A1

  公开（公告）日：2021-05-06

  The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.
• US4111697A
  申请人：——

  公开号：US4111697A

  公开（公告）日：1978-09-05
• [EN] CHIRAL CONTROL<br/>[FR] CONTRÔLE CHIRAL
  申请人：ONTORII INC

  公开号：WO2014012081A2

  公开（公告）日：2014-01-16

  The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same.
• [EN] OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF<br/>[FR] COMPOSITIONS D'OLIGONUCLÉOTIDES ET PROCÉDÉS ASSOCIÉS
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2017062862A2

  公开（公告）日：2017-04-13

  Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.