1-(2-hydroxy-ethyl)-pyridinium | 45705-62-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(2-hydroxy-ethyl)-pyridinium
• 英文别名: 1-<2-Hydroxy-ethyl>-pyridinium；N-<2-Hydroxy-ethyl>-pyridinium；2-Pyridin-1-ium-1-ylethanol
• CAS: 45705-62-2
• 化学式: C₇H₁₀NO
• 分子量: 124.162
• InChiKey: KGWNHXCBHOVEOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  24.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(2-hydroxy-ethyl)-pyridinium 、 4-已氧基苯甲酰氯 在 sodium tetrahydroborate 作用下， 生成
  参考文献：
  名称：

  毒蕈碱ACh受体的新型长效拮抗剂。

  摘要：

  背景与目的本研究的目的是开发有效的长效毒蕈碱型ACh受体拮抗剂。合成了1- [2-（4-氧化苯甲酰氧基）乙基] -1，2，3，6-四氢吡啶-1-基的4-己氧基和4-丁氧基衍生物，并对其生物学活性进行了测试。在受体上具有长驻留时间的拮抗剂是治疗几种神经系统和精神科人类疾病的治疗靶标。它们的长效作用可减少每日剂量和不良反应。实验方法在表达毒蕈碱受体个别亚型的CHO细胞中研究了由4-己氧基氧基化合物介导的对激动剂卡巴胆碱的功能反应的结合和拮抗作用，并将其与4-丁氧基类似物进行了比较。关键结果发现4-己氧基衍生物以微摩尔亲和力结合毒蕈碱受体，并拮抗对卡巴胆碱的功能性反应，效力范围从M1受体的30 nM到M3受体的4μM。在逆转拮抗作用的洗涤条件下，其拮抗作用的半衰期在M2受体的1.7 h至M5受体的5 h。结论和意义发现4-己氧基衍生物是强效的长效M1拮抗剂。根据当前文献，M1-选择性拮抗剂可能对

  DOI：

  10.1111/bph.14187

文献信息

• [EN] CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS DE CYCLOHEXÈNE-BENZOTRIAZOLE
  申请人：MERCK SHARP & DOHME

  公开号：WO2012151138A1

  公开（公告）日：2012-11-08

  The present invention is directed to cyclohexene benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及环己烯苯并三唑衍生物，这些衍生物是代谢型谷氨酸受体的增强剂，特别是mGluR2受体，可用于治疗或预防与谷氨酸功能障碍有关的神经和精神障碍，以及代谷氨酸受体参与的疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗代谷氨酸受体参与的疾病中的用途。
• BITOPIC MUSCARINIC AGONISTS AND ANTAGONISTS AND METHODS OF SYNTHESIS AND USE THEREOF
  申请人：BARRY UNIVERSITY, INC.

  公开号：US20160136145A1

  公开（公告）日：2016-05-19

  Compositions for treating a condition associated with activity of a muscarinic receptor (e.g., one or more of M 1 , M 2 , M 3 , M 4 , M 5 ) and for anesthetizing a subject include a bitopic muscarinic antagonist or agonist. A bitopic muscarinic antagonist named JB-D4 was discovered. Additional bitopic muscarinic antagonists discovered and described herein include BK-23, HD-42, HD153, HD-185, KH-5, JM-31 and JM-32. These bitopic ligands and their structural analogs, as well as bitopic muscarinic agonists, may be used as neuromuscular blocking agents (e.g., for use in compositions for anesthetizing a subject) and for the treatment of central nervous system disorders (e.g., Parkinson's disease, Schizophrenia, etc.), Overactive Bladder Syndrome, Chronic Obstructive Pulmonary Disease, asthma, and many other diseases associated with the activation or inhibition of M 1 -M 5 acetylcholine receptors.

  用于治疗与肌肉乙酰胆碱受体活性有关的疾病（例如M1、M2、M3、M4、M5中的一个或多个）和麻醉受试者的组合物包括一个双位点肌肉乙酰胆碱受体拮抗剂或激动剂。一种双位点肌肉乙酰胆碱受体拮抗剂命名为JB-D4已被发现。此外，还发现并描述了其他双位点肌肉乙酰胆碱受体拮抗剂，包括BK-23、HD-42、HD153、HD-185、KH-5、JM-31和JM-32。这些双位点配体及其结构类似物，以及双位点肌肉乙酰胆碱受体激动剂，可用作神经肌肉阻滞剂（例如用于麻醉受试者的组合物）以及用于治疗中枢神经系统疾病（例如帕金森病、精神分裂症等）、过度活动性膀胱综合症、慢性阻塞性肺疾病、哮喘和许多与M1-M5乙酰胆碱受体的激活或抑制有关的疾病。
• DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND AN INDOLE COUPLER
  申请人：Couroux Anne-Marie

  公开号：US20120278997A1

  公开（公告）日：2012-11-08

  The subject of the present invention is dye composition for keratin fibres, comprising, in suitable dyeing medium, a coupler of formula (I) or addition salts thereof with an acid a particular cationic or noncationic aminopyrazolopyridine derivative. The composition of the present invention makes it possible in particular to obtain a colouring with varied, intense and/or chromatic, aesthetic and relatively nonselective shades which are highly resistant to the various attacks to which the hair may be subjected.

  本发明的主题是用于角蛋白纤维的染料组合物，包括在适当的染料介质中，式（I）的偶联剂或其与酸的加成盐，以及特定的阳离子或非阳离子氨基吡唑吡啶衍生物。本发明的组合物特别能够获得具有多样、强烈和/或色彩的、美观和相对非选择性的阴影，这些阴影对头发可能遭受的各种攻击具有高度的抵抗力。
• Method for manufacturing stabilized polyacetal resin, stabilized polyacetal resin, stabilized polyacetal resin composition, and molded article of stabilized polyacetal resin
  申请人：Polyplastics Co., Ltd.

  公开号：EP1867667A1

  公开（公告）日：2007-12-19

  The present invention provides an agent to decompose unstable terminal group, which is effective in a small adding amount, which sufficiently decreases the quantity of residual unstable terminal group, and which generates very little limitation on the treatment method, the apparatus, and the use amount of the agent. Specifically, it provides a method for manufacturing stabilized polyacetal resin having the step of applying heat treatment to a polyacetal resin having an unstable terminal group in the presence of an agent to decompose the unstable terminal group, which agent is composed of a heterocyclic quaternary ammonium salt, thus decreasing the quantity of the unstable terminal group.

  本发明提供了一种分解不稳定末端基团的药剂，其添加量小，效果好，能充分减少残留的不稳定末端基团的数量，并且对处理方法、装置和药剂的使用量限制很小。具体地说，它提供了一种制造稳定聚缩醛树脂的方法，该方法的步骤是：在有药剂存在的情况下，对具有不稳定末端基团的聚缩醛树脂进行热处理，以分解不稳定末端基团，该药剂由杂环季铵盐组成，从而减少不稳定末端基团的数量。
• REAGENT FOR MEASUREMENT OF CONCENTRATION OF LEAD, AND METHOD FOR MEASUREMENT OF CONCENTRATION OF LEAD
  申请人：Kowa Co., Ltd.

  公开号：EP2169399A1

  公开（公告）日：2010-03-31

  To provide a lead concentration determination reagent which realizes accurate, high-sensitivity, and simple-manner determination of the lead ion concentration (also referred to simply as "lead concentration") of a sample solution in the presence of calcium ions, and a lead concentration determination method employing the reagent. The lead concentration determination reagent contains (A) a water-soluble porphyrin derivative or a salt thereof, (B) at least one member selected from among polyacrylamide, polyvinyl alcohol, and polyethylene glycol, and (C) a calcium-ion-supplying compound.

  提供一种铅浓度测定试剂，该试剂可以准确、高灵敏度、简便地测定存在钙离子的样品溶液中的铅离子浓度（也简称为 "铅浓度"），以及使用该试剂的铅浓度测定方法。 铅浓度测定试剂包含 (A) 水溶性卟啉衍生物或其盐，(B) 至少一种选自聚丙烯酰胺、聚乙烯醇和聚乙二醇的成分，以及 (C) 钙离子供应化合物。