1-Bis--2-methyl-3-phenyl-propen-(1) | 19293-79-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Bis--2-methyl-3-phenyl-propen-(1)
• 英文别名: (1-methyl-2-phenyl-ethylidene)-malonic acid diethyl ester；(1-Methyl-2-phenyl-aethyliden)-malonsaeure-diaethylester；Diethyl (1-phenylpropan-2-ylidene)propanedioate；diethyl 2-(1-phenylpropan-2-ylidene)propanedioate
• CAS: 19293-79-9
• 化学式: C₁₆H₂₀O₄
• 分子量: 276.332
• InChiKey: QPURPBFEBRECLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-Bis--2-methyl-3-phenyl-propen-(1) 在 氢氧化钾 作用下， 生成 1-Hydroxy-3-methyl-2-naphthoic acid
  参考文献：
  名称：

  Marion; McRae, Canadian Journal of Research, Section B: Chemical Sciences, 1940, vol. 18, p. 265,270

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1-bis(ethoxycarbonyl)-2-methyl-3-phenylcyclopropane 在 iron(III) chloride 作用下， 以 二氯甲烷 为溶剂， 以77 %的产率得到1-Bis--2-methyl-3-phenyl-propen-(1)
  参考文献：
  名称：

  Knoevenagel 加合物的一碳同系化：对映选择性获得二苯甲基衍生物

  摘要：

  据报道，Knoevenagel 加合物的一碳同系物能够插入 CHAr 片段。该策略涉及硫叶立德介导的环丙烷化，然后进行环丙烷的重排，并能够合成一系列二苯甲基衍生物。机理研究表明，环丙烷重排涉及路易斯酸催化的开环，然后是芳基的 1,2-迁移。证明了使用手性锍叶立德控制生成的立体烯丙基碳中心的绝对立体化学的可能性。

  DOI：

  10.1021/acs.joc.4c00057

文献信息

• Marion; McRae, Canadian Journal of Research, Section B: Chemical Sciences, 1940, vol. 18, p. 265,270
  作者：Marion、McRae

  DOI：——

  日期：——
• Genetic studies in representatives of genusRhipidomys (Rodentia, Sigmodontinae) from Brazil
  作者：Jaqueline Andrades-Miranda、Luiz F. B. de Oliveira、C. André V. Lima-Rosa、Denis A. Sana、Andrea P. Nunes、Margarete S. Mattevi

  DOI：10.1007/bf03192453

  日期：2002.6

  Karyotypic polymorphism of five taxa of the rodent genus Rhipidomys from the Brazilian Amazon and Cerrado biomes was analysed. Rhipidomys nitela Thomas, 1901 from Amazon has 2n = 48, FN = 68. The other species, all have 2n = 44, but can be separated into two groups, one with high FNs (76, 80) and the other with low FNs (48, 52). Two cytotypes of R. mastacalis (Lund, 1840) with high FNs were trapped in four localities of the Cerrado, showing 19 and 17 biarmed autosomes, respectively. A low FN (48) was observed in R. leucodactylus (Tschudi, 1844) in two localities of the Cerrado and FN = 52 in one locality in the Cerrado and the Amazon. All taxa with 2n = 44 have a medium-sized acrocentric X chromosome and a small Y. Rhipidomys nitela is different from the species with 2n = 44 by presenting a heterochromatic short arm of the X chromosome. In all karyotypes analysed, the nucleolus organizer regions were located in the short arms of two to six pairs and the (T(2)AG(3))(n) telomeric probes hybridized in situ in both the short and long arms of all pairs of the karyotypes.
• 10.1021/acs.joc.4c00057
  作者：Janssens, Julien、De Roose, Madeline、Jacquemin, Alexis、Vanhosmael, Thomas、Delbrassinne, Arnaud、Collard, Laurent、Robiette, Raphaël

  DOI：10.1021/acs.joc.4c00057

  日期：——

  fragment is reported. The strategy involves a sulfur ylide mediated cyclopropanation followed by the rearrangement of cyclopropanes and enables the synthesis of a series of benzhydryl derivatives. Mechanistic studies reveal that the cyclopropane rearrangement involves a Lewis acid catalyzed ring-opening followed by the 1,2-migration of an aryl group. The possibility of controlling the absolute stereochemistry

  据报道，Knoevenagel 加合物的一碳同系物能够插入 CHAr 片段。该策略涉及硫叶立德介导的环丙烷化，然后进行环丙烷的重排，并能够合成一系列二苯甲基衍生物。机理研究表明，环丙烷重排涉及路易斯酸催化的开环，然后是芳基的 1,2-迁移。证明了使用手性锍叶立德控制生成的立体烯丙基碳中心的绝对立体化学的可能性。