1-Hydroxy-3-methyl-2-naphthoic acid | 22890-54-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Hydroxy-3-methyl-2-naphthoic acid
• 英文别名: 1-hydroxy-3-methyl-[2]naphthoic acid；1-Hydroxy-3-methyl-[2]naphthoesaeure；1-Hydroxy-3-methylnaphthalene-2-carboxylic acid
• CAS: 22890-54-6
• 化学式: C₁₂H₁₀O₃
• 分子量: 202.21
• InChiKey: VCDFRDMNYQOQMC-UHFFFAOYSA-N

物化性质

• 沸点：
  376.3±30.0 °C(Predicted)
• 密度：
  1.341±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Hydroxy-3-methyl-2-naphthoic acid 在 喹啉 、 铜 作用下， 生成 3-甲基-1-萘酚
  参考文献：
  名称：

  Marion; McRae, Canadian Journal of Research, Section B: Chemical Sciences, 1940, vol. 18, p. 265,270

  摘要：

  DOI：
• 作为产物：
  描述：

  1-Bis--2-methyl-3-phenyl-propen-(1) 在 氢氧化钾 作用下， 生成 1-Hydroxy-3-methyl-2-naphthoic acid
  参考文献：
  名称：

  Marion; McRae, Canadian Journal of Research, Section B: Chemical Sciences, 1940, vol. 18, p. 265,270

  摘要：

  DOI：

文献信息

• Carbon–hydrogen and C–X (X = Cl or SiMe₃) bond activation. 1-Cyclopalladation and oxidation of some derivatives of 2-[(dimethylamino)methyl]naphthalene
  作者：Jean-Marc Valk、Ruud van Belzen、Jaap Boersma、Anthony L. Spek、Gerard van Koten

  DOI：10.1039/dt9940002293

  日期：——

  1-bromo-2-[(dimethylamino)methyl]naphthalene to [Pd(dba)2](dba = dibenzylideneacetone). Protection of C(3) with R = SiMe3 resulted in quantitative replacement of the SiMe3 group by palladium. Silicon–oxygen bond cleavage was observed when the substrate with R = OSiMe3 was treated with Pd(O2CMe)2. Palladium bis3-[(dimethylamino)methyl]-2-naphtholate} was obtained quantitatively. Oxidation of several arylpalladium complexes

  研究了2-[（（二甲基氨基）甲基]萘的3-取代衍生物，C 10 H 6（CH 2 NMe 2）-2-R-3（R = Cl，SiMe 3或OSiMe 3）的区域选择性palpalation反应。。对于具有R = Cl的底物，在位置1处未观察到环钯，并分离出配位配合物。通过C–Cl活化可形成10％收率的3-palpald产品。2-[（（二甲氨基）甲基] -3-甲基萘与Pd（O 2 CMe）2的反应并且用LiCl处理确实导致了位置1的心，分离出的复合物的收率为96％。解析了双（乙腈）2-[（（二甲基氨基）甲基] -3-甲基-1-萘基}钯三氟甲烷磺酸盐的晶体结构。单斜晶系，空间群P 2 1 / n，a = 13.193（1），b = 11.801（1），c = 14.797（1）Å，β= 105.15（1）°，Z = 4。对于I >2.5σ（I）的3455次反射，R = 0.042 。通过将1-
• HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES
  申请人：Olesen Preben Houlberg

  公开号：US20100041657A1

  公开（公告）日：2010-02-18

  The present invention relates to compounds of formula I, in which at least one of R5, R6 and R7 is SR12, S(O)R12 or S(O)2R12 group where R12 is a C1-6haloalkyl group, that act, as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.

  本发明涉及公式I的化合物，其中R5，R6和R7中至少有一个是SR12，S（O）R12或S（O）2R12基团，其中R12是C1-6卤代烷基基团，可作为化学解偶联剂。本发明的化合物在治疗，包括预防肥胖症，糖尿病以及与之相关的许多疾病或病况方面非常有用。
• Heat-sensitive adhesive agent and heat-sensitive adhesive sheet
  申请人：Ricoh Company, Ltd.

  公开号：EP1897925A1

  公开（公告）日：2008-03-12

  Provided is a heat-sensitive adhesive agent that mainly comprises a thermoplastic resin and a heat-meltable substance capable of melting upon heating, and further comprises swellable mica.

  本发明提供了一种热敏粘合剂，它主要由热塑性树脂和加热时能够熔化的热熔物质组成，还包括可膨胀云母。
• Genetic studies in representatives of genusRhipidomys (Rodentia, Sigmodontinae) from Brazil
  作者：Jaqueline Andrades-Miranda、Luiz F. B. de Oliveira、C. André V. Lima-Rosa、Denis A. Sana、Andrea P. Nunes、Margarete S. Mattevi

  DOI：10.1007/bf03192453

  日期：2002.6

  Karyotypic polymorphism of five taxa of the rodent genus Rhipidomys from the Brazilian Amazon and Cerrado biomes was analysed. Rhipidomys nitela Thomas, 1901 from Amazon has 2n = 48, FN = 68. The other species, all have 2n = 44, but can be separated into two groups, one with high FNs (76, 80) and the other with low FNs (48, 52). Two cytotypes of R. mastacalis (Lund, 1840) with high FNs were trapped in four localities of the Cerrado, showing 19 and 17 biarmed autosomes, respectively. A low FN (48) was observed in R. leucodactylus (Tschudi, 1844) in two localities of the Cerrado and FN = 52 in one locality in the Cerrado and the Amazon. All taxa with 2n = 44 have a medium-sized acrocentric X chromosome and a small Y. Rhipidomys nitela is different from the species with 2n = 44 by presenting a heterochromatic short arm of the X chromosome. In all karyotypes analysed, the nucleolus organizer regions were located in the short arms of two to six pairs and the (T(2)AG(3))(n) telomeric probes hybridized in situ in both the short and long arms of all pairs of the karyotypes.
• Heat-sensitive adhesive material
  申请人：Ricoh Company, Ltd.

  公开号：EP1634936B1

  公开（公告）日：2008-08-06