O-butyl S-triphenylstannyl carbonodithioate | 89154-66-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: O-butyl S-triphenylstannyl carbonodithioate
• 英文别名: [(Butoxycarbonothioyl)sulfanyl](triphenyl)stannane；O-butyl triphenylstannylsulfanylmethanethioate
• CAS: 89154-66-5
• 化学式: C₂₃H₂₄OS₂Sn
• 分子量: 499.285
• InChiKey: PTMWGZRGIPRKLL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.49
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丁基黄原酸钾 、 三苯基氯化锡 以 甲醇 为溶剂， 反应 4.0h， 以92%的产率得到O-butyl S-triphenylstannyl carbonodithioate
  参考文献：
  名称：

  Organotin(IV) O-butyl carbonodithioates: Synthesis, characterization, in vitro bioactivities, and interaction with SS-DNA

  摘要：

  Organotin(IV) O-butyl carbonodithioates [Me2SnL2], [Bu2SnL2], [Ph2SnL2], [Bu3SnL], and [Ph3SnL], where L = C4H9OCS (2) (-) , have been successfully synthesized and characterized by FT-IR, H-1 and C-13 NMR, and single crystal X-ray analysis. The ligand coordinates to the tin atom via the carbonodithioate group. According to the X-ray diffraction data, the tin atom in [Me2SnL2] has distorted tetrahedral geometry. The synthesized compounds were screened in vitro for antibacterial, antifungal, antileishmanial, cytotoxic, and protein kinase inhibitory activities. The complexes [Bu3SnL] and [Ph3SnL] exhibited the highest anti-leishmanial activity that exceeded the activity of the reference drug amphotericin B, probably by blocking the function of parasitic mitochondria due to which it restricts further growth of the organisms. The ligand and the complexes have been shown to bind to DNA via intercalative interactions resulting in hypochromic effect with a minor red shift as confirmed by UV-Vis spectroscopic studies.

  DOI：

  10.1134/s1070363216120380

文献信息

• SRIVASTAVA, T. N.;RASTOGI, R. B.;KAPOOR, R. S., NAT. ACAD. SCI. LETT., 1982, 5, N 12, 415-420
  作者：SRIVASTAVA, T. N.、RASTOGI, R. B.、KAPOOR, R. S.

  DOI：——

  日期：——
• Organotin(IV) O-butyl carbonodithioates: Synthesis, characterization, in vitro bioactivities, and interaction with SS-DNA
  作者：F. Javed、S. Ali、S. Shahzadi、M. N. Tahir、S. Tabassum、N. Khalid

  DOI：10.1134/s1070363216120380

  日期：2016.12

  Organotin(IV) O-butyl carbonodithioates [Me2SnL2], [Bu2SnL2], [Ph2SnL2], [Bu3SnL], and [Ph3SnL], where L = C4H9OCS (2) (-) , have been successfully synthesized and characterized by FT-IR, H-1 and C-13 NMR, and single crystal X-ray analysis. The ligand coordinates to the tin atom via the carbonodithioate group. According to the X-ray diffraction data, the tin atom in [Me2SnL2] has distorted tetrahedral geometry. The synthesized compounds were screened in vitro for antibacterial, antifungal, antileishmanial, cytotoxic, and protein kinase inhibitory activities. The complexes [Bu3SnL] and [Ph3SnL] exhibited the highest anti-leishmanial activity that exceeded the activity of the reference drug amphotericin B, probably by blocking the function of parasitic mitochondria due to which it restricts further growth of the organisms. The ligand and the complexes have been shown to bind to DNA via intercalative interactions resulting in hypochromic effect with a minor red shift as confirmed by UV-Vis spectroscopic studies.