N-[4-(4-Methoxy-phenyl)-butyl]-hydroxylamine | 134304-40-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-(4-Methoxy-phenyl)-butyl]-hydroxylamine
• 英文别名: N-[4-(4-methoxyphenyl)butyl]hydroxylamine
• CAS: 134304-40-8
• 化学式: C₁₁H₁₇NO₂
• 分子量: 195.261
• InChiKey: IYYKYKVRHNUMTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-甲氧基-4-(4-硝基丁基)苯 在 samarium diiodide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 0.05h， 以72%的产率得到N-[4-(4-Methoxy-phenyl)-butyl]-hydroxylamine
  参考文献：
  名称：

  二碘化sa可控制地将硝基烷还原为烷基羟胺或胺

  摘要：

  烷基羟胺和烷基胺已由硝基烷和SmI 2在温和的条件下以中等至良好的收率制备。

  DOI：

  10.1016/s0040-4039(00)74307-3

文献信息

• Hydroxylamine derivatives
  申请人：Newron Pharmaceuticals S.p.A.

  公开号：EP1541547A1

  公开（公告）日：2005-06-15

  This invention is related to hydroxylamino derivatives of the following general formula (I) wherein    n is 0, 1 or 2;    R1 and R2, independently of each other, are H, OH or OCH3;    R3 is H or CH3;    R4 is H, C1-C3 straight or branched alkyl or, together with R3, forms a five to seven-membered carbocyclic ring;    and R5 and R6, independently of each other, are H or C1-C5 straight or branched alkyl and the pharmaceutically acceptable salts or prodrug thereof, for the preparation of medicaments useful for the prevention, treatment and diagnosis of CNS degenerative disorders related to protein misfolding and/or misaggregation. The invention also relates to novel compounds included in formula (I), to a method for preparing said compounds and to pharmaceutical compositions containing them.

  这项发明涉及以下一般式（I）的羟胺衍生物， 其中    n为0、1或2；    R1和R2，彼此独立，为H、OH或OCH3；    R3为H或CH3；    R4为H、C1-C3直链或支链烷基，或者与R3一起形成五至七元碳环；    而R5和R6，彼此独立，为H或C1-C5直链或支链烷基 以及其药学上可接受的盐或前药，用于制备用于预防、治疗和诊断与蛋白质错误折叠和/或错误聚集相关的中枢神经系统退行性疾病的药物。 该发明还涉及包含在式（I）中的新化合物，制备这些化合物的方法以及含有它们的药物组合物。
• HYDROXYLAMINE DERIVATIVES
  申请人：CACCIA Carla

  公开号：US20100197799A1

  公开（公告）日：2010-08-05

  This invention is related to hydroxylamino derivatives of the following general formula (I) wherein n is 0, 1 or 2; R 1 and R 2 , independently of each other, are H, OH or OCH 3 ; R 3 is H or CH 3 ; R 4 is H, C 1 -C 3 straight or branched alkyl or, together with R 3 , forms a five to seven-membered carbocyclic ring; and R 5 and R 6 , independently of each other, are H or C 1 -C 5 straight or branched alkyl and the pharmaceutically acceptable salts or prodrug thereof, for the preparation of medicaments useful for the prevention, treatment and diagnosis of CNS degenerative disorders related to protein misfolding and/or misaggregation. The invention also relates to novel compounds included in formula (I), to a method for preparing the compounds and to pharmaceutical compositions containing them.

  本发明涉及以下通式（I）的羟胺衍生物，其中n为0、1或2；R1和R2独立地为H、OH或OCH3；R3为H或CH3；R4为H、C1-C3直链或支链烷基或与R3一起形成五元至七元的碳环；R5和R6独立地为H或C1-C5直链或支链烷基，以及其药学上可接受的盐或前药，用于制备有益于预防、治疗和诊断与蛋白质错折和/或错聚相关的中枢神经系统退行性疾病的药物。本发明还涉及包括式（I）中的新化合物、制备该化合物的方法以及含有它们的药物组合物。
• US7763751B2
  申请人：——

  公开号：US7763751B2

  公开（公告）日：2010-07-27
• [EN] HYDROXYLAMINE DERIVATIVES<br/>[FR] DERIVES D'HYDROXYLAMINE
  申请人：NEWRON PHARM SPA

  公开号：WO2005058800A1

  公开（公告）日：2005-06-30

  This invention is related to hydroxylamino derivatives of the general formula (I) wherein n is 0, l or 2; R1 and R2, independently of each other, are H, OH or OCH3; R3 is H or CH3; R4 is H, C1-C3 straight or branched alkyl or, together with R3, forms a five to seven-membered carbocyclic ring; and R5 and R6, independently of each other, are H or C1-C5 straight or branched alkyl and the pharmaceutically acceptable salts or prodrug thereof, for the preparation of medicaments useful for the prevention, treatment and diagnosis of CNS degenerative disorders related to protein misfolding and/or misaggregation. The invention also relates to novel compounds included in formula (I), to a method for preparing said compounds and to pharmaceutical compositions containing them.
• Controlled reduction of nitroalkanes to alkyl hydroxylamines or amines by samarium diiodide
  作者：Andrew S. Kende、José S. Mendoza

  DOI：10.1016/s0040-4039(00)74307-3

  日期：1991.4

  Alkyl hydroxylamines and alkyl amines have been prepared from nitroalkanes and SmI2 under mild conditions in moderate to good yields.

  烷基羟胺和烷基胺已由硝基烷和SmI 2在温和的条件下以中等至良好的收率制备。