1-nitrooxymethyl-(6-methoxy)-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole | 384339-54-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-nitrooxymethyl-(6-methoxy)-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
• 英文别名: [6-Methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-yl]methyl nitrate
• CAS: 384339-54-2
• 化学式: C₁₈H₂₀N₄O₆S
• 分子量: 420.446
• InChiKey: ANBZWEZXCDJNEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  141
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-sulfinyl]-1-[chloromethyl]-1H-benzimidazole 在 silver nitrate 作用下， 以 乙腈 为溶剂， 生成 1-nitrooxymethyl-(6-methoxy)-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
  参考文献：
  名称：

  Compounds useful as antibacterial agents

  摘要：

  本发明涉及一种新的化合物I的化合物，以及其药学上可接受的盐，作为抗菌剂。本发明的化合物是质子泵抑制剂的一氧化氮释放衍生物（NO释放PPIs）。另外，本发明涉及本发明的化合物用于治疗的方法；制备这种新化合物的方法；包含至少一种本发明的化合物或其药学上可接受的盐作为活性成分的药物组合物；以及将活性化合物用于制造上述医用药物的用途。本发明还涉及用于制备新化合物的新中间体。此外，本发明还涉及NO释放PPIs与其他已知药物的联合给药。

  公开号：

  US20020111370A1

文献信息

• NEW COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS
  申请人：AstraZeneca AB

  公开号：EP1370551A2

  公开（公告）日：2003-12-17
• US6673819B2
  申请人：——

  公开号：US6673819B2

  公开（公告）日：2004-01-06
• [EN] NEW COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS<br/>[FR] NOUVEAUX COMPOSES UTILES COMME AGENTS ANTIBACTERIENS
  申请人：ASTRAZENECA AB

  公开号：WO2002000166A2

  公开（公告）日：2002-01-03

  The present invention relates to novel compounds of Formula I, and pharmaceutically acceptable salts thereof, as antibacterial agents. The compounds of the present invention are nitric oxide releasing derivatives of proton pump inhibitors (NO-releasing PPIs). In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above. The invention also relates to new intermediates for use in the preparation of the novel compounds. Additionally the present invention relates to co-administration of NO-releasing PPIs with other known medicaments.
• Compounds useful as antibacterial agents
  申请人：——

  公开号：US20020111370A1

  公开（公告）日：2002-08-15

  The present invention relates to novel compounds of Formula I, and pharmaceutically acceptable salts thereof, as antibacterial agents. The compounds of the present invention are nitric oxide releasing derivatives of proton pump inhibitors (NO-releasing PPIs). In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above. The invention also relates to new intermediates for use in the preparation of the novel compounds. Additionally the present invention relates to co-administration of NO-releasing PPIs with other known medicaments. 1

  本发明涉及一种新的化合物I的化合物，以及其药学上可接受的盐，作为抗菌剂。本发明的化合物是质子泵抑制剂的一氧化氮释放衍生物（NO释放PPIs）。另外，本发明涉及本发明的化合物用于治疗的方法；制备这种新化合物的方法；包含至少一种本发明的化合物或其药学上可接受的盐作为活性成分的药物组合物；以及将活性化合物用于制造上述医用药物的用途。本发明还涉及用于制备新化合物的新中间体。此外，本发明还涉及NO释放PPIs与其他已知药物的联合给药。