N-异丁基-3-苯基-2-丙炔-1-胺 | 347406-04-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-异丁基-3-苯基-2-丙炔-1-胺
• 英文名称: N-isobutyl-3-phenyl-2-propyn-1-amine
• 英文别名: 2-methyl-N-(3-phenylprop-2-ynyl)propan-1-amine
• CAS: 347406-04-6
• 化学式: C₁₃H₁₇N
• mdl: MFCD07405938
• 分子量: 187.285
• InChiKey: KSFKLXBUVKKPCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.384
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921499090

反应信息

• 作为产物：
  描述：

  2-methyl-N-(3-phenyl-2-propynylidene)-1-propanamine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.33h， 以82%的产率得到N-异丁基-3-苯基-2-丙炔-1-胺
  参考文献：
  名称：

  In Situ Oxidation−Imine Formation−Reduction Routes from Alcohols to Amines

  摘要：

  [GRAPHICS]Manganese dioxide is employed as an in situ oxidant for the one pot conversion of alcohols into imines, In combination with polymer-supported cyanoborohydride (PSCBH), a one-pot oxidation-imine formation-reduction sequence is reported, This procedure enables alcohols to be converted directly into both secondary and tertiary amines.

  DOI：

  10.1021/ol015819b

文献信息

• A one-pot oxidation–imine formation–reduction route from alcohols to amines using manganese dioxide–sodium borohydride: the synthesis of naftifine
  作者：Hisashi Kanno、Richard J.K. Taylor

  DOI：10.1016/s0040-4039(02)01722-7

  日期：2002.10

  A new procedure for the one-pot conversion of alcohols into amines is described which utilises manganese dioxide in the presence of sodium borohydride; the scope of this process is outlined, as is its application to the preparation of the topical antifungal agent, naftifine. (C) 2002 Elsevier Science Ltd. All rights reserved.
• In Situ Oxidation−Imine Formation−Reduction Routes from Alcohols to Amines
  作者：Leonie Blackburn、Richard J. K. Taylor

  DOI：10.1021/ol015819b

  日期：2001.5.1

  [GRAPHICS]Manganese dioxide is employed as an in situ oxidant for the one pot conversion of alcohols into imines, In combination with polymer-supported cyanoborohydride (PSCBH), a one-pot oxidation-imine formation-reduction sequence is reported, This procedure enables alcohols to be converted directly into both secondary and tertiary amines.