3-((S)-1-amino-3-hydroxypropyl)benzonitrile hydrochloride | 1391439-21-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-((S)-1-amino-3-hydroxypropyl)benzonitrile hydrochloride
• 英文别名: 3-[(1S)-1-amino-3-hydroxypropyl]benzonitrile;hydrochloride
• CAS: 1391439-21-6
• 化学式: C₁₀H₁₂N₂O*ClH
• 分子量: 212.679
• InChiKey: KRKROQWQUYOGGI-PPHPATTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.36
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  70
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,5,6,6-tetramethyl-2-(4-nitrophenoxy)-5,6-dihydro-1,4,3-oxathiazine 4,4-dioxide 、 3-((S)-1-amino-3-hydroxypropyl)benzonitrile hydrochloride 在 氨 、 盐酸 、 乙酸乙酯 、 Sodium sulfate-III 、 C17H23N3O4S 作用下， 以 二氯甲烷 、 N,N-二异丙基乙胺 为溶剂， 反应 16.0h， 以After lyophilization of the product-containing fractions, the product (66 mg) was thus obtained with a molecular weight of 365.5 g/mol (C17H23N3O4S)的产率得到3-[(S)-3-hydroxy-1-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ6-[1,4,3]oxathiazin-2-ylamino)propyl]benzonitrile
  参考文献：
  名称：

  Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof

  摘要：

  本发明涉及式(I)的化合物及其生理上可接受的盐。所述化合物适用于例如治疗高血糖等方面。

  公开号：

  US08871758B2
• 作为产物：
  描述：

  N-[(S)-3-(tert-butyldimethylsilanyloxy)-1-(3-cyanophenyl)propyl]-(S_S)-2-methylpropane-2-sulfinamide 在 盐酸 、 甲醇 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 生成 3-((S)-1-amino-3-hydroxypropyl)benzonitrile hydrochloride
  参考文献：
  名称：

  DI- AND TRI-SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF

  摘要：

  该发明涉及式(I)的化合物及其生理兼容盐。所述化合物适用于治疗高血糖，例如。

  公开号：

  US20130345125A1

文献信息

• DI AND TRI - SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF
  申请人：Boehme Thomas

  公开号：US20130338150A1

  公开（公告）日：2013-12-19

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  该发明涉及公式（I）的化合物及其生理兼容盐。这些化合物适用于治疗高血糖，例如。
• TETRASUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, THEIR USE AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND THE USE THEREOF
  申请人：Boehme Thomas

  公开号：US20140024584A1

  公开（公告）日：2014-01-23

  The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.

  该发明涉及式(I)的化合物以及其生理上可接受的盐。所述化合物适用于治疗高血糖等情况。
• Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
  申请人：Boehme Thomas

  公开号：US08710050B2

  公开（公告）日：2014-04-29

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  本发明涉及式(I)化合物及其生理相容盐。该化合物适用于治疗高血糖等疾病。
• Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
  申请人：Boehme Thomas

  公开号：US08828994B2

  公开（公告）日：2014-09-09

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  本发明涉及公式(I)的化合物及其生理相容盐。该化合物适用于治疗高血糖等疾病。