3-Benzyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one | 158271-98-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Benzyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one
• 英文别名: 4-benzyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2H-pyrrol-5-one
• CAS: 158271-98-8
• 化学式: C₁₉H₁₉NO₂
• 分子量: 293.365
• InChiKey: DHDVUHZKHLVYSL-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Benzyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one 在 盐酸 、 lithium diisopropyl amide 作用下， 以 二氯甲烷 为溶剂， 生成 (3R,6S,7aS)-6-Benzyl-6-methyl-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one
  参考文献：
  名称：

  Diastereoselective bis-alkylation of chiral non-racemic α,β-unsaturated γ-lactams

  摘要：

  A new chiral non-racemic gamma-lactam 1 easily prepared in one step from (R)-(-)-phenylglycinol was bis-alkylated alpha to the carbonyl function in very high to complete diastereoselectivity. The stereochemistry at the so-formed chiral quaternary center was ascertained through an X-ray crystallographic study.

  DOI：

  10.1016/s0040-4039(00)76705-0
• 作为产物：
  描述：

  (S)-(+)-1-苯基-1,2-乙二醇 在 盐酸 、 lithium diisopropyl amide 作用下， 反应 3.0h， 生成 3-Benzyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one
  参考文献：
  名称：

  Diastereoselective bis-alkylation of chiral non-racemic α,β-unsaturated γ-lactams

  摘要：

  A new chiral non-racemic gamma-lactam 1 easily prepared in one step from (R)-(-)-phenylglycinol was bis-alkylated alpha to the carbonyl function in very high to complete diastereoselectivity. The stereochemistry at the so-formed chiral quaternary center was ascertained through an X-ray crystallographic study.

  DOI：

  10.1016/s0040-4039(00)76705-0

文献信息

• Baussanne Isabelle, Chiaroni Angele, Husson Henri-Philippe, Riche Claude,+, Tetrahedron Lett, 35 (1994) N 23, S 3931-3934
  作者：Baussanne Isabelle, Chiaroni Angele, Husson Henri-Philippe, Riche Claude,+

  DOI：——

  日期：——
• Diastereoselective bis-alkylation of chiral non-racemic α,β-unsaturated γ-lactams
  作者：Isabelle Baussanne、Angèle Chiaroni、Henri-Philippe Husson、Claude Riche、Jacques Royer

  DOI：10.1016/s0040-4039(00)76705-0

  日期：1994.6

  A new chiral non-racemic gamma-lactam 1 easily prepared in one step from (R)-(-)-phenylglycinol was bis-alkylated alpha to the carbonyl function in very high to complete diastereoselectivity. The stereochemistry at the so-formed chiral quaternary center was ascertained through an X-ray crystallographic study.