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    —— 8-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]-2-(4-ethylphenyl)-6-(3-hydroxy-4-methoxyphenyl)-6a-methyl-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone —— C43H39ClN4O6S
    8-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]-2-(4-ethylphenyl)-6-(3-hydroxy-4-methoxyphenyl)-6a-methyl-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone
    —— 8-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]-6-(2-hydroxy-4,6-dimethoxyphenyl)-6a-methyl-2-(4-morpholin-4-ylphenyl)-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone —— C46H44ClN5O8S
    8-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]-6-(2-hydroxy-4,6-dimethoxyphenyl)-6a-methyl-2-(4-morpholin-4-ylphenyl)-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone
    —— 8-benzyl-4-methyl-2-[(2S)-1-(2-phenylacetyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C27H28N4O2
    8-benzyl-4-methyl-2-[(2S)-1-(2-phenylacetyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(3-fluorophenyl)methyl]-4-methyl-2-[(2R)-1-(pyridine-3-carbonyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C25H24FN5O2
    8-[(3-fluorophenyl)methyl]-4-methyl-2-[(2R)-1-(pyridine-3-carbonyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-(cyclohexylmethyl)-2-[(3R)-1-(2-methoxyacetyl)piperidin-3-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C23H34N4O3
    8-(cyclohexylmethyl)-2-[(3R)-1-(2-methoxyacetyl)piperidin-3-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-(3-chloro-4-fluorophenyl)-2-(4-ethenylphenyl)-6-(2-hydroxy-3-methoxyphenyl)-6a-methyl-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone —— C36H30ClFN2O6
    8-(3-chloro-4-fluorophenyl)-2-(4-ethenylphenyl)-6-(2-hydroxy-3-methoxyphenyl)-6a-methyl-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone
    —— 8-benzyl-4-methyl-2-[(2R)-1-(pyridine-3-carbonyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C25H25N5O2
    8-benzyl-4-methyl-2-[(2R)-1-(pyridine-3-carbonyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(3-fluorophenyl)methyl]-4-methyl-2-[(2S)-1-(2-phenylethyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C27H29FN4O
    8-[(3-fluorophenyl)methyl]-4-methyl-2-[(2S)-1-(2-phenylethyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-benzyl-4-methyl-2-[(2S)-1-(2-pyridin-4-ylacetyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H27N5O2
    8-benzyl-4-methyl-2-[(2S)-1-(2-pyridin-4-ylacetyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-benzyl-2-[(2S)-1-(2-methoxyacetyl)pyrrolidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C22H26N4O3
    8-benzyl-2-[(2S)-1-(2-methoxyacetyl)pyrrolidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(3-fluorophenyl)methyl]-4-methyl-2-[(2S)-1-(pyridine-3-carbonyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C25H24FN5O2
    8-[(3-fluorophenyl)methyl]-4-methyl-2-[(2S)-1-(pyridine-3-carbonyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(3-fluorophenyl)methyl]-2-[(2R)-1-(2-methoxyacetyl)pyrrolidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C22H25FN4O3
    8-[(3-fluorophenyl)methyl]-2-[(2R)-1-(2-methoxyacetyl)pyrrolidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(3-fluorophenyl)methyl]-4-methyl-2-[(2R)-1-(2-phenylethyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C27H29FN4O
    8-[(3-fluorophenyl)methyl]-4-methyl-2-[(2R)-1-(2-phenylethyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-methoxy-2-oxo-N-(4-phenyl-1,3-thiazol-2-yl)-2H-chromene-3-carboxamide —— C20H14N2O4S
    8-methoxy-2-oxo-N-(4-phenyl-1,3-thiazol-2-yl)-2H-chromene-3-carboxamide
    —— 8-(cyclohexylmethyl)-4-methyl-2-[(3S)-1-(1H-pyrazole-5-carbonyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C24H32N6O2
    8-(cyclohexylmethyl)-4-methyl-2-[(3S)-1-(1H-pyrazole-5-carbonyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-(cyclohexylmethyl)-4-methyl-2-[(3S)-1-(pyridine-3-carbonyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H33N5O2
    8-(cyclohexylmethyl)-4-methyl-2-[(3S)-1-(pyridine-3-carbonyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-Benzyl-2-[[cyclohexyl(methyl)amino]methyl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C23H30N4O
    8-Benzyl-2-[[cyclohexyl(methyl)amino]methyl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(3-fluorophenyl)methyl]-2-[(2S)-1-(2-methoxyacetyl)pyrrolidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C22H25FN4O3
    8-[(3-fluorophenyl)methyl]-2-[(2S)-1-(2-methoxyacetyl)pyrrolidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3R)-1-(pyridin-3-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H28FN5O
    8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3R)-1-(pyridin-3-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3S)-1-(pyridin-2-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H28FN5O
    8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3S)-1-(pyridin-2-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-(cyclohexylmethyl)-2-[(3S)-1-[2-(dimethylamino)acetyl]piperidin-3-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C24H37N5O2
    8-(cyclohexylmethyl)-2-[(3S)-1-[2-(dimethylamino)acetyl]piperidin-3-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-benzyl-4-methyl-2-[(2R)-1-(pyridine-3-carbonyl)piperidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H27N5O2
    8-benzyl-4-methyl-2-[(2R)-1-(pyridine-3-carbonyl)piperidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-(cyclohexylmethyl)-4-methyl-2-[(3R)-1-(pyridine-3-carbonyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H33N5O2
    8-(cyclohexylmethyl)-4-methyl-2-[(3R)-1-(pyridine-3-carbonyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-(cyclohexylmethyl)-2-[(3R)-1-[2-(dimethylamino)acetyl]piperidin-3-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C24H37N5O2
    8-(cyclohexylmethyl)-2-[(3R)-1-[2-(dimethylamino)acetyl]piperidin-3-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(3-fluorophenyl)methyl]-2-[(2R)-1-[(4-fluorophenyl)methyl]pyrrolidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H26F2N4O
    8-[(3-fluorophenyl)methyl]-2-[(2R)-1-[(4-fluorophenyl)methyl]pyrrolidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3S)-1-(pyridin-4-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H28FN5O
    8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3S)-1-(pyridin-4-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-(2,4-dichloroanilino)-6-[2-(4-hydroxy-3-methoxyphenyl)ethenyl]-6a-(4-methoxyphenyl)-2-propyl-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone —— C39H37Cl2N3O7
    8-(2,4-dichloroanilino)-6-[2-(4-hydroxy-3-methoxyphenyl)ethenyl]-6a-(4-methoxyphenyl)-2-propyl-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone
    —— 8-[(3-fluorophenyl)methyl]-2-[(2S)-1-[(4-fluorophenyl)methyl]pyrrolidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H26F2N4O
    8-[(3-fluorophenyl)methyl]-2-[(2S)-1-[(4-fluorophenyl)methyl]pyrrolidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-(cyclohexylmethyl)-4-methyl-2-[(3S)-1-(pyridin-2-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H35N5O
    8-(cyclohexylmethyl)-4-methyl-2-[(3S)-1-(pyridin-2-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-benzyl-2-[(2R)-1-(cyclohexanecarbonyl)piperidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C27H34N4O2
    8-benzyl-2-[(2R)-1-(cyclohexanecarbonyl)piperidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-benzyl-4-methyl-2-[(2S)-1-(2-pyridin-2-ylacetyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H27N5O2
    8-benzyl-4-methyl-2-[(2S)-1-(2-pyridin-2-ylacetyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3R)-1-(pyridin-4-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H28FN5O
    8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3R)-1-(pyridin-4-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-(cyclohexylmethyl)-2-[(3R)-1-(cyclopentanecarbonyl)piperidin-3-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H38N4O2
    8-(cyclohexylmethyl)-2-[(3R)-1-(cyclopentanecarbonyl)piperidin-3-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-benzyl-4-methyl-2-[(2R)-1-(2-phenylacetyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C27H28N4O2
    8-benzyl-4-methyl-2-[(2R)-1-(2-phenylacetyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-benzyl-4-methyl-2-[(2R)-1-(2-pyridin-2-ylacetyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H27N5O2
    8-benzyl-4-methyl-2-[(2R)-1-(2-pyridin-2-ylacetyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(2-methoxyphenyl)methyl]-4-methyl-2-[(2S)-1-(1H-pyrazole-5-carbonyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C24H26N6O3
    8-[(2-methoxyphenyl)methyl]-4-methyl-2-[(2S)-1-(1H-pyrazole-5-carbonyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3S)-1-(pyridin-3-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H28FN5O
    8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3S)-1-(pyridin-3-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-benzyl-2-[(2R)-1-(2-methoxyacetyl)pyrrolidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C22H26N4O3
    8-benzyl-2-[(2R)-1-(2-methoxyacetyl)pyrrolidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-(cyclohexylmethyl)-4-methyl-2-[(3R)-1-(pyridin-4-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H35N5O
    8-(cyclohexylmethyl)-4-methyl-2-[(3R)-1-(pyridin-4-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3R)-1-(pyridin-2-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H28FN5O
    8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3R)-1-(pyridin-2-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3S)-1-(1H-pyrazole-5-carbonyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C24H25FN6O2
    8-[(2-fluorophenyl)methyl]-4-methyl-2-[(3S)-1-(1H-pyrazole-5-carbonyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-(cyclohexylmethyl)-4-methyl-2-[(3R)-1-(1H-pyrazole-5-carbonyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C24H32N6O2
    8-(cyclohexylmethyl)-4-methyl-2-[(3R)-1-(1H-pyrazole-5-carbonyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-benzyl-2-[(2S)-1-(cyclohexanecarbonyl)piperidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C27H34N4O2
    8-benzyl-2-[(2S)-1-(cyclohexanecarbonyl)piperidin-2-yl]-4-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-(cyclohexylmethyl)-4-methyl-2-[(3R)-1-(pyridin-2-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C26H35N5O
    8-(cyclohexylmethyl)-4-methyl-2-[(3R)-1-(pyridin-2-ylmethyl)piperidin-3-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— 8-[(2-methoxyphenyl)methyl]-4-methyl-2-[(2R)-1-(1H-pyrazole-5-carbonyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one —— C24H26N6O3
    8-[(2-methoxyphenyl)methyl]-4-methyl-2-[(2R)-1-(1H-pyrazole-5-carbonyl)pyrrolidin-2-yl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
    —— (8-hydroxy-5,8-dimethyl-1-methylidene-2-oxo-5,5a,6,7,8a,9-hexahydro-4H-azuleno[6,5-b]furan-6-yl) acetate —— C17H22O5
    (8-hydroxy-5,8-dimethyl-1-methylidene-2-oxo-5,5a,6,7,8a,9-hexahydro-4H-azuleno[6,5-b]furan-6-yl) acetate
    —— 8-(4-bromophenyl)-1,3-dimethyl-7-(3-nitrophenyl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione —— C21H15BrN6O4
    8-(4-bromophenyl)-1,3-dimethyl-7-(3-nitrophenyl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
    —— 8-(3-chlorophenyl)-6-(4-hydroxy-3-methylphenyl)-2-(4-nitrophenyl)-6a-phenyl-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone —— C39H30ClN3O7
    8-(3-chlorophenyl)-6-(4-hydroxy-3-methylphenyl)-2-(4-nitrophenyl)-6a-phenyl-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone
    —— 8-(Bromomethyl)-2-(4-bromophenyl)-6a,9a-dichloro-6-(3-hydroxyphenyl)-3a,4,6,10,10a,10b-hexahydroisoindolo[5,6-e]isoindole-1,3,7,9-tetrone —— C27H20Br2Cl2N2O5
    8-(Bromomethyl)-2-(4-bromophenyl)-6a,9a-dichloro-6-(3-hydroxyphenyl)-3a,4,6,10,10a,10b-hexahydroisoindolo[5,6-e]isoindole-1,3,7,9-tetrone
    —— 8-Methoxy-2-[[4-[6-methyl-4-(1-methylpyrazol-4-yl)pyridin-2-yl]piperidin-1-yl]methyl]quinoline —— C26H29N5O
    8-Methoxy-2-[[4-[6-methyl-4-(1-methylpyrazol-4-yl)pyridin-2-yl]piperidin-1-yl]methyl]quinoline