1D-N,N'-diacetyl-O⁴-[(2S)-3c-acetylamino-6-(acetylamino-methyl)-3,4-dihydro-2H-pyran-2r-yl]-O⁶-[4-methyl-3-(N-methyl-2,4-dinitro-anilino)-β-L-3-deoxy-arabinopyranosyl]-2-deoxy-streptamine | 66762-57-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1D-N,N'-diacetyl-O⁴-[(2S)-3c-acetylamino-6-(acetylamino-methyl)-3,4-dihydro-2H-pyran-2r-yl]-O⁶-[4-methyl-3-(N-methyl-2,4-dinitro-anilino)-β-L-3-deoxy-arabinopyranosyl]-2-deoxy-streptamine
• CAS: 66762-57-0
• 化学式: C₃₃H₄₇N₇O₁₅
• 分子量: 781.774
• InChiKey: DBDMGQZNHSYRCU-CSLZDPSESA-N

反应信息

• 作为反应物：
  描述：

  1D-N,N'-diacetyl-O⁴-[(2S)-3c-acetylamino-6-(acetylamino-methyl)-3,4-dihydro-2H-pyran-2r-yl]-O⁶-[4-methyl-3-(N-methyl-2,4-dinitro-anilino)-β-L-3-deoxy-arabinopyranosyl]-2-deoxy-streptamine 以 N,N-二甲基甲酰胺 为溶剂， 生成 1D-N,N'-diacetyl-O⁴-[(2S)-3c-acetylamino-6-(acetylamino-methyl)-3,4-dihydro-2H-pyran-2r-yl]-O⁶-[N,O⁴-methanediyl-4-methyl-3-(4-nitro-2-nitroso-anilino)-β-L-3-deoxy-arabinopyranosyl]-2-deoxy-streptamine
  参考文献：
  名称：

  Chemical modification of some gentamicins and sisomicin at the 3"-position.

  摘要：

  Chemical and photochemical oxidative methods of de-N-methylation of some gentamicins and sisomicins at the 3"-position are described. Selective acetylation of gentamicins and sisomicins at the 1, 3, 2' and 6' and of gentamicin B at the 1, 3, and 6' positions are achieved by treatment of the free bases with carbon dioxide prior to acetylation. De-N-methylation of the above selectively blocked gentamicins and sisomicins followed by re-alkylation at the 3"-position and de-N-protection gives a series of 3"-N-alkyl analogues. The in vitro antibacterialproperties of the new derivatives of gentamicins and sisomicins are given.

  DOI：

  10.7164/antibiotics.31.43