7α-carboxymethyl-17,20,20,21-bismethylenedioxy-5-pregnene-3,20-dione 3-ethylene ketal | 64735-35-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 7α-carboxymethyl-17,20,20,21-bismethylenedioxy-5-pregnene-3,20-dione 3-ethylene ketal
• CAS: 64735-35-9
• 化学式: C₂₇H₃₈O₈
• 分子量: 490.594
• InChiKey: PNGWQTUTYXILTG-DSBBFUSGSA-N

反应信息

• 作为反应物：
  描述：

  7α-carboxymethyl-17,20,20,21-bismethylenedioxy-5-pregnene-3,20-dione 3-ethylene ketal 在 甲酸 作用下， 反应 120.0h， 生成 7α-carboxymethyl-17,21-dihydroxy-4-pregnene-3,20-dione
  参考文献：
  名称：

  7α- and 7β-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol. Synthesis and immunogenic properties

  摘要：

  7 alpha- and 7 beta-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol have been synthesized. After coupling to bovine serum albumin, they were used to elicit antibodies in rabbits. No major difference in the steroid specificity of the antisera was observed when either 7 alpha- or 7 beta-epimers were used for immunization. In both cases, highly specific antisera were obtained which may possibly be used to assay human plasma 17-hydroxyprogesterone and 11-deoxycortisol without chromatographic purification.

  DOI：

  10.1016/0039-128x(80)90112-9
• 作为产物：
  描述：

  7-bromo-17,20,20,21-bismethylenedioxy-5-pregnene-3,20-dione 3-ethylene ketal 、 丙二酸二乙酯 在 氢氧化钾 、 sodium hydride 作用下， 生成 7α-carboxymethyl-17,20,20,21-bismethylenedioxy-5-pregnene-3,20-dione 3-ethylene ketal 、 7β-carboxymethyl-17,20,20,21-bismethylenedioxy-5-pregnene-3,20-dione 3-ethylene ketal
  参考文献：
  名称：

  7α- and 7β-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol. Synthesis and immunogenic properties

  摘要：

  7 alpha- and 7 beta-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol have been synthesized. After coupling to bovine serum albumin, they were used to elicit antibodies in rabbits. No major difference in the steroid specificity of the antisera was observed when either 7 alpha- or 7 beta-epimers were used for immunization. In both cases, highly specific antisera were obtained which may possibly be used to assay human plasma 17-hydroxyprogesterone and 11-deoxycortisol without chromatographic purification.

  DOI：

  10.1016/0039-128x(80)90112-9