| 85709-89-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• CAS: 85709-89-3
• 化学式: C₁₀H₁₅O₂Se*Cl
• 分子量: 277.681
• InChiKey: DMKOVGLFTWXVML-FOHXBPHZSA-N

反应信息

• 作为产物：
  描述：

  在 三氯化硼 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  New selenium-75 labeled radiopharmaceuticals: selenonium analogs of dopamine

  摘要：

  Selenium-75 labeled selenonium analogues of dopamine, [2-(3,4-dimethoxyphenyl)ethyl]dimethylselenonium iodide (4) and its dihydroxy analogue (7), were prepared by reducing [75Se]selenious acid with sodium borohydride at pH 6.0 and reacting the NaSeH produced with 1-(3,4-dimethoxyphenyl)-2-(p-toluenesulfonyloxy)ethane. Tissue distribution studies in rats given the 75Se-labeled selenonium agents intravenously demonstrated high initial heart uptake (2.38% dose/g at 5 min). Prolonged adrenal retention (t1/2 = 10 h) and high adrenal to blood ratio of compound 4 (21/1 at 4 h after injection) were observed. The high uptake and adrenal to blood ratio suggest the potential use of compound 4 as a radiopharmaceutical for the adrenal gland.

  DOI：

  10.1021/jm00361a003