| 122751-63-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• CAS: 122751-63-7
• 化学式: C₅₁H₆₅N₃O₁₂
• 分子量: 912.09
• InChiKey: RQKKOKSQAKJOOT-LLQOIWJESA-N

反应信息

• 作为反应物：
  描述：

  在 甲酸 作用下， 以1.75 g的产率得到
  参考文献：
  名称：

  Hypolipidemic activity of rifamycin derivatives

  摘要：

  Series of 3-piperidinyl- and 3-piperazinylrifamycins and to a certain extent 3-hydrazonorifamycins all bearing lipophilic side chains were found to exert potent hypolipidemic activity in lowering both serum cholesterol and LDL-cholesterol in rats. Starting from 3-[N'-(2,4,6-trimethylbenzyl)-N-piperazinyl]rifamycin SV (compound 25), a series of derivatives were synthesized with the aim of dissociating the hypolipidemic from the antibacterial activity, leading to the 8-O,N-dipivaloyl derivative of 25 (compound 48), which is devoid of any antibacterial activity but shows about 50-60% reduction of LDL-cholesterol and 20-30% reduction of serum cholesterol at a dose of 10 mg/kg. Compound 48 was selected for further pharmacological evaluation.

  DOI：

  10.1021/jm00164a013