8-Chloro-5-methyl-12H-11-thia-6,12-diaza-dibenzo[a,f]azulene | 153528-07-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: 8-Chloro-5-methyl-12H-11-thia-6,12-diaza-dibenzo[a,f]azulene
• CAS: 153528-07-5
• 化学式: C₁₆H₁₁ClN₂S
• 分子量: 298.796
• InChiKey: SVJOVEZDKZIYKC-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  8-Chloro-5-methyl-12H-11-thia-6,12-diaza-dibenzo[a,f]azulene 、 碘甲烷 在 氢氧化钾 、 四丁基溴化铵 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以80%的产率得到8-Chloro-5,12-dimethyl-12H-11-thia-6,12-diaza-dibenzo[a,f]azulene
  参考文献：
  名称：

  Synthesis, antimicrobial and cytostatic activities of some derivatives of indolo[2,3-b]-1,5-benzothiazepine, a novel heterocyclic ring system

  摘要：

  Some derivatives of indolo[2,3-b]-1,5-benzothiazepine, a novel heterocyclic ring system, and of its 5,6-dihydroderivative have been obtained by Fischer indolization of corresponding phenylhydrazones. All the tetracyclic compounds were studied for their antimicrobial and cytostatic activities and several of them showed good activity against Gram-positive bacteria and Cryptococci.

  DOI：

  10.1016/0223-5234(93)90024-9
• 作为产物：
  描述：

  7-chloro-4-methyl-1,5-benzothiazepin-2(3H)-one 在 盐酸 、 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 1.25h， 生成 8-Chloro-5-methyl-12H-11-thia-6,12-diaza-dibenzo[a,f]azulene
  参考文献：
  名称：

  Synthesis, antimicrobial and cytostatic activities of some derivatives of indolo[2,3-b]-1,5-benzothiazepine, a novel heterocyclic ring system

  摘要：

  Some derivatives of indolo[2,3-b]-1,5-benzothiazepine, a novel heterocyclic ring system, and of its 5,6-dihydroderivative have been obtained by Fischer indolization of corresponding phenylhydrazones. All the tetracyclic compounds were studied for their antimicrobial and cytostatic activities and several of them showed good activity against Gram-positive bacteria and Cryptococci.

  DOI：

  10.1016/0223-5234(93)90024-9