| 1261252-67-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• CAS: 1261252-67-8
• 化学式: C₁₅H₁₃ClFN₃
• 分子量: 289.74
• InChiKey: OAQIMTMXHRGFBN-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 生成 9-fluoro-6-(isopropylamino)benzo[c]-1,6-naphthyridin-1(2H)-one
  参考文献：
  名称：

  The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: Hit to lead

  摘要：

  This paper describes the discovery and design of a novel class of JAK2 inhibitors. Furthermore, we detail the optimization of a screening hit using ligand binding efficiency and log D. These efforts led to the identification of compound 41, which demonstrates in vivo activity in our study. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.10.031