(1S,4aR,4bR,6aS,12aS,12bR,14aR)-10-Methoxy-1,4a,6a,12b-tetramethyl-2,3,4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-tetradecahydro-1H-7-oxa-benzo[b]chrysene-1-carbaldehyde | 646522-30-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (1S,4aR,4bR,6aS,12aS,12bR,14aR)-10-Methoxy-1,4a,6a,12b-tetramethyl-2,3,4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-tetradecahydro-1H-7-oxa-benzo[b]chrysene-1-carbaldehyde
• CAS: 646522-30-7
• 化学式: C₂₇H₃₈O₃
• 分子量: 410.597
• InChiKey: PESZOQZESONWRW-NPLGQECHSA-N

反应信息

• 作为反应物：
  描述：

  (1S,4aR,4bR,6aS,12aS,12bR,14aR)-10-Methoxy-1,4a,6a,12b-tetramethyl-2,3,4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-tetradecahydro-1H-7-oxa-benzo[b]chrysene-1-carbaldehyde 在 氢氧化钾 、 一水合肼 作用下， 以 二乙二醇 为溶剂， 反应 4.5h， 以77%的产率得到strongylophorine-22 methyl ether
  参考文献：
  名称：

  New Strongylophorines from the Okinawan Marine Sponge Petrosia (Strongylophora) corticata

  摘要：

  New strongylophorines-22 (1), -23 (2), -24 (3), and -25 (4) were isolated from the Okinawan sponge Petrosia (Strongylophora) corticata along with other known strongylophorines. The structures of these strongylophorines were determined on the basis of spectroscopic analysis and chemical conversions. Assessment was also made of the cytotoxicity of strongylophorines-1, -2, -3, -4, -22 (1), -23 (2), and -24 (3) toward HeLa cells.

  DOI：

  10.1021/np030312q
• 作为产物：
  描述：

  ((1S,4aR,4bR,6aS,12aS,12bR,14aR)-10-Methoxy-1,4a,6a,12b-tetramethyl-2,3,4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-tetradecahydro-1H-7-oxa-benzo[b]chrysen-1-yl)-methanol 在 4 A molecular sieve 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以80%的产率得到(1S,4aR,4bR,6aS,12aS,12bR,14aR)-10-Methoxy-1,4a,6a,12b-tetramethyl-2,3,4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-tetradecahydro-1H-7-oxa-benzo[b]chrysene-1-carbaldehyde
  参考文献：
  名称：

  New Strongylophorines from the Okinawan Marine Sponge Petrosia (Strongylophora) corticata

  摘要：

  New strongylophorines-22 (1), -23 (2), -24 (3), and -25 (4) were isolated from the Okinawan sponge Petrosia (Strongylophora) corticata along with other known strongylophorines. The structures of these strongylophorines were determined on the basis of spectroscopic analysis and chemical conversions. Assessment was also made of the cytotoxicity of strongylophorines-1, -2, -3, -4, -22 (1), -23 (2), and -24 (3) toward HeLa cells.

  DOI：

  10.1021/np030312q