3β-acetoxy-16α-iodomethyl-13α-androst-5-en-17β-ol | 939401-78-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β-acetoxy-16α-iodomethyl-13α-androst-5-en-17β-ol
• CAS: 939401-78-2
• 化学式: C₂₂H₃₃IO₃
• 分子量: 472.407
• InChiKey: KWIODZDAKBUHPN-KETNVUDHSA-N

反应信息

• 作为反应物：
  描述：

  3β-acetoxy-16α-iodomethyl-13α-androst-5-en-17β-ol 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 0.33h， 以84%的产率得到3β-hydroxy-16α-iodomethyl-13α-androst-5-en-17β-ol
  参考文献：
  名称：

  Synthesis of D-seco-13α-Androst-5-ene Derivatives

  摘要：

  3 beta-Hydroxy-16,17-seco-13 alpha-androsta-5,16-dien-17-a1 was obtained from 3 beta-acetoxyandrost-5-en-17-one in six steps with a Grob fragmentation as the key step. This seco-steroid, containing a formyl group and an unsaturated side-chain in a sterically favourable cis position, is a useful synthon for the synthesis of novel heterocycles condensed to the 3 beta-hydroxy-13 alpha-androst-5-en-17-one skeleton.

  DOI：

  10.1007/s00706-005-0500-y
• 作为产物：
  描述：

  3β-acetoxy-16-hydroxymethyl-13α-androst-5-en-17-ol 在 咪唑 、 碘 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以72%的产率得到3β-acetoxy-16α-iodomethyl-13α-androst-5-en-17β-ol
  参考文献：
  名称：

  Synthesis of D-seco-13α-Androst-5-ene Derivatives

  摘要：

  3 beta-Hydroxy-16,17-seco-13 alpha-androsta-5,16-dien-17-a1 was obtained from 3 beta-acetoxyandrost-5-en-17-one in six steps with a Grob fragmentation as the key step. This seco-steroid, containing a formyl group and an unsaturated side-chain in a sterically favourable cis position, is a useful synthon for the synthesis of novel heterocycles condensed to the 3 beta-hydroxy-13 alpha-androst-5-en-17-one skeleton.

  DOI：

  10.1007/s00706-005-0500-y