| 1314775-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• CAS: 1314775-26-2
• 化学式: C₂₆H₂₇NO₃S
• 分子量: 433.571
• InChiKey: IPLDQGSQWUXEQF-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以47%的产率得到3-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-(4-hydroxyphenyl)-1-benzothiophen-6-ol
  参考文献：
  名称：

  Parallel Synthesis of a Desketoraloxifene Analogue Library via Iodocyclization/Palladium-Catalyzed Coupling

  摘要：

  For a future structure-activity relationship (SAR) study, a library of desketoraloxifene analogues has been prepared by parallel synthesis using iodocyclization and subsequent palladium-catalyzed coupling reactions. Points of desketoraloxifene diversification involve the two phenolic hydroxyl groups and the aliphatic amine side chain. This approach affords oxygen bearing 3-iodobenzo[b]thiophenes 4 in excellent yields, which are easily further elaborated using a two-step approach involving Suzuki-Miyaura and Mitsunobu coupling reactions to give multimethoxy-substituted desketoraloxifene analogues 6. Various hydroxyl-substituted desketoraloxifene analogues 7 were subsequently generated by demethylation with BBr(3).

  DOI：

  10.1021/co200090p