3,10-bis(t-butyl-dimethylsilyloxy)-benz[c]xanthene-7-one | 1069133-02-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3,10-bis(t-butyl-dimethylsilyloxy)-benz[c]xanthene-7-one
• CAS: 1069133-02-3
• 化学式: C₂₉H₃₈O₄Si₂
• 分子量: 506.789
• InChiKey: SIXQNJGHKAKQBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.87
• 重原子数：
  35.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  48.67
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3,10-bis(t-butyl-dimethylsilyloxy)-benz[c]xanthene-7-one 、 4-({lithium chloride, magnesium chloride}-carboxy)-2-methyl-phenyl magnesium chloride 在 盐酸 作用下， 以 水 为溶剂， 反应 8.0h， 以90%的产率得到(3,10-dihydroxy-benz[c]xanthene-7-yl)-4-carboxy-2-methylbenzene
  参考文献：
  名称：

  Nonclassical SNAPFL Analogue as a Cy5 Resonance Energy Transfer Partner

  摘要：

  We have synthesized a new SNAPFL analogue (1) that exhibits a large Stokes shift (78 nm) (abs. 542 nm, em. 620 nm) and a good quantum yield. Because of the large overlap between the emission spectrum of 1 and the absorption spectrum of Cy5, 1 functions well as a fluorescence donor to Cy5 and has been used in FRET-based experiments using estrogen receptor site-specifically labeled with Cy5 and a receptor ligand conjugated to SNAPFL.

  DOI：

  10.1021/ol801907b
• 作为产物：
  描述：

  3,10-dihydroxy-benz[c]xanthene-7-one 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以89%的产率得到3,10-bis(t-butyl-dimethylsilyloxy)-benz[c]xanthene-7-one
  参考文献：
  名称：

  Nonclassical SNAPFL Analogue as a Cy5 Resonance Energy Transfer Partner

  摘要：

  We have synthesized a new SNAPFL analogue (1) that exhibits a large Stokes shift (78 nm) (abs. 542 nm, em. 620 nm) and a good quantum yield. Because of the large overlap between the emission spectrum of 1 and the absorption spectrum of Cy5, 1 functions well as a fluorescence donor to Cy5 and has been used in FRET-based experiments using estrogen receptor site-specifically labeled with Cy5 and a receptor ligand conjugated to SNAPFL.

  DOI：

  10.1021/ol801907b