| 1227941-38-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1227941-38-9
• 化学式: C₂₃H₁₆ClFN₂O
• 分子量: 390.844
• InChiKey: JUHDEIDSQHILRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.87
• 重原子数：
  28.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  33.2
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  在 氨 、 palladium diacetate 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 1,4-二氧六环 、 水 为溶剂， 生成 N-(2-aminopyridin-4-yl)-N-(4-fluorobenzyl)-2-naphthamide
  参考文献：
  名称：

  Amide-based inhibitors of p38α MAP kinase. Part 1: Discovery of novel N-pyridyl amide lead molecules

  摘要：

  A novel series of N-pyridyl amides as potent p38 alpha kinase inhibitors is described. Based on the structural similarities between the initial hit and a well-known imidazole pyrimidine series of p38 alpha inhibitors, potencies within the newly discovered series were quickly improved by installation of an (S)-alpha-methylbenzyl moiety at the 2-position of the pyridine ring. The proposed binding modes of the new series to p38 alpha were evaluated against SAR findings and provided rationale for further development of this series of molecules. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.088
• 作为产物：
  描述：

  naphthalene-2-carboxylic acid (2-chloro-pyridin-4-yl)-amide 、 4-氟溴苄 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Amide-based inhibitors of p38α MAP kinase. Part 1: Discovery of novel N-pyridyl amide lead molecules

  摘要：

  A novel series of N-pyridyl amides as potent p38 alpha kinase inhibitors is described. Based on the structural similarities between the initial hit and a well-known imidazole pyrimidine series of p38 alpha inhibitors, potencies within the newly discovered series were quickly improved by installation of an (S)-alpha-methylbenzyl moiety at the 2-position of the pyridine ring. The proposed binding modes of the new series to p38 alpha were evaluated against SAR findings and provided rationale for further development of this series of molecules. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.088