| 1148002-17-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• CAS: 1148002-17-8
• 化学式: C₅₃H₄₆Cl₂N₈O₁₃P₂S₅
• 分子量: 1296.18
• InChiKey: JHKXFKHHWCIDDR-JEABHORZSA-N

物化性质

• 密度：
  1.74±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  12.81
• 重原子数：
  83.0
• 可旋转键数：
  22.0
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  278.71
• 氢给体数：
  4.0
• 氢受体数：
  25.0

反应信息

• 作为反应物：
  描述：

  在 (E)-pyridin-2-aldoxime 、 四甲基胍 、 氨 、 水 作用下， 以 吡啶 为溶剂， 反应 40.0h， 生成
  参考文献：
  名称：

  Self-Organization, Optical, and Electrical Properties of α-Quinquethiophene-Dinucleotide Conjugates

  摘要：

  AbstractBiodriven self‐organization of α‐quinquethiophene (t5): Cast films of 5′TA3′‐t5 are electroactive, photoluminescent, and chiral. Their growth is not directed by intermolecular Watson–Crick hydrogen bonding between the A⋅⋅⋅T moieties of interacting molecules, but is governed by intra‐ and intermolecular thiophene–nucleobase stacking interactions.magnified imageThe synthesis and properties of 5′TA3′‐t5 (8 a) and 5′CG3′‐t5 (8 b) conjugates, in which the self‐complementary dinucleotides TA and CG are covalently bound to the central ring of α‐quinquethiophene (t5), are described. According to molecular mechanics calculations, the preferred conformation of both 8 a and 8 b is that with the dinucleotide folded over the planar t5 backbone, with the nucleobases facing t5 at stacking distance. The calculations show that the aggregation process of 8 a and 8 b is driven by a mix of nucleobase‐thiophene interactions, hydrogen bonding between nucleobases (non Watson–Crick (W&C) in TA, and W&C in CG), van der Waals, and electrostatic interactions. While 8 b is scarcely soluble in any solvents, 8 a is soluble in water, indicating that the aggregates of the former are more stable than those of the latter. Microfluidic‐induced self‐assembly studies of 8 a showed the formation of lamellar, spherulitic, and dendritic supramolecular structures, depending on the concentration and solvent evaporation time. The self‐assembled structures displayed micrometer dimensions in the xy plane of the substrate and nanometer dimensions in the z direction. Spatially resolved confocal microscopy and spectroscopy showed that the aggregates were characterized by intense fluorescence emission. Cast films of 8 a from water solutions showed chirality transfer from the dinucleotide to t5. The hole mobility of the cast films of 8 a was estimated using a two‐electrode device under high vacuum and found to be up to two orders of magnitude greater than those previously measured for dinucleotide–quarterthiophene conjugates under the same experimental conditions.

  DOI：

  10.1002/chem.200801684
• 作为产物：
  描述：

  在 甲醇 、 苯磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以58%的产率得到
  参考文献：
  名称：

  Self-Organization, Optical, and Electrical Properties of α-Quinquethiophene-Dinucleotide Conjugates

  摘要：

  AbstractBiodriven self‐organization of α‐quinquethiophene (t5): Cast films of 5′TA3′‐t5 are electroactive, photoluminescent, and chiral. Their growth is not directed by intermolecular Watson–Crick hydrogen bonding between the A⋅⋅⋅T moieties of interacting molecules, but is governed by intra‐ and intermolecular thiophene–nucleobase stacking interactions.magnified imageThe synthesis and properties of 5′TA3′‐t5 (8 a) and 5′CG3′‐t5 (8 b) conjugates, in which the self‐complementary dinucleotides TA and CG are covalently bound to the central ring of α‐quinquethiophene (t5), are described. According to molecular mechanics calculations, the preferred conformation of both 8 a and 8 b is that with the dinucleotide folded over the planar t5 backbone, with the nucleobases facing t5 at stacking distance. The calculations show that the aggregation process of 8 a and 8 b is driven by a mix of nucleobase‐thiophene interactions, hydrogen bonding between nucleobases (non Watson–Crick (W&C) in TA, and W&C in CG), van der Waals, and electrostatic interactions. While 8 b is scarcely soluble in any solvents, 8 a is soluble in water, indicating that the aggregates of the former are more stable than those of the latter. Microfluidic‐induced self‐assembly studies of 8 a showed the formation of lamellar, spherulitic, and dendritic supramolecular structures, depending on the concentration and solvent evaporation time. The self‐assembled structures displayed micrometer dimensions in the xy plane of the substrate and nanometer dimensions in the z direction. Spatially resolved confocal microscopy and spectroscopy showed that the aggregates were characterized by intense fluorescence emission. Cast films of 8 a from water solutions showed chirality transfer from the dinucleotide to t5. The hole mobility of the cast films of 8 a was estimated using a two‐electrode device under high vacuum and found to be up to two orders of magnitude greater than those previously measured for dinucleotide–quarterthiophene conjugates under the same experimental conditions.

  DOI：

  10.1002/chem.200801684