N-(2-bromo-6-chloro-pyridin-3-yl)-acetamide | 1352823-81-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-bromo-6-chloro-pyridin-3-yl)-acetamide
• 英文别名: N-(2-Bromo-6-chloropyridin-3-yl)acetamide；N-(2-bromo-6-chloropyridin-3-yl)acetamide
• CAS: 1352823-81-4
• 化学式: C₇H₆BrClN₂O
• 分子量: 249.494
• InChiKey: NHVGLMBNSCXDPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-bromo-6-chloro-pyridin-3-yl)-acetamide 在 劳森试剂 作用下， 以 1,4-二氧六环 为溶剂， 以89.8%的产率得到5-氯-2-甲基噻唑并[5,4-b]吡啶
  参考文献：
  名称：

  [EN] 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS
  [FR] 7H-PYRROLO[2, 3-D]PYRIMIDINES ET LEUR PRÉPARATION ET LEURS UTILISATIONS

  摘要：

  7H-Pyrrolo[2,3-d]pyrimidine compounds of Formula (I) for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 7H-pyrrolo[2,3-d]pyrimidine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRKIA (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

  公开号：

  WO2023064361A1
• 作为产物：
  描述：

  3-氨基-2-溴-6-氯吡啶 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 以83.2%的产率得到N-(2-bromo-6-chloro-pyridin-3-yl)-acetamide
  参考文献：
  名称：

  [EN] 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS
  [FR] 7H-PYRROLO[2, 3-D]PYRIMIDINES ET LEUR PRÉPARATION ET LEURS UTILISATIONS

  摘要：

  7H-Pyrrolo[2,3-d]pyrimidine compounds of Formula (I) for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 7H-pyrrolo[2,3-d]pyrimidine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRKIA (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

  公开号：

  WO2023064361A1

文献信息

• [EN] BIPHENYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES<br/>[FR] DÉRIVÉS DE 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDÈNE-AMINE À SUBSTITUTION BIPHÉNYLE
  申请人：NOVARTIS AG

  公开号：WO2011157787A1

  公开（公告）日：2011-12-22

  The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of one or more IGF-1 R mediated disorders or diseases.

  这项发明涉及公式（I）的新衍生物，其中取代基如规范中所定义；制备这种衍生物的方法；包括这种衍生物的药物组合物；将这种衍生物用作药物；将这种衍生物用于治疗一个或多个IGF-1 R介导的疾病。
• BIPHENYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES
  申请人：Berst Frederic

  公开号：US20130090342A1

  公开（公告）日：2013-04-11

  The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of one or more IGF-1R mediated disorders or diseases.

  该发明涉及公式（I）的新衍生物，其中取代基如规范中定义；制备这种衍生物的过程；包含这种衍生物的药物组合物；这种衍生物作为药物；这种衍生物用于治疗一个或多个IGF-1R介导的疾病或疾病的方法。
• [EN] 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS<br/>[FR] 7H-PYRROLO[2, 3-D]PYRIMIDINES ET LEUR PRÉPARATION ET LEURS UTILISATIONS
  申请人：[en]BIOSPLICE THERAPEUTICS, INC.

  公开号：WO2023064361A1

  公开（公告）日：2023-04-20

  7H-Pyrrolo[2,3-d]pyrimidine compounds of Formula (I) for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 7H-pyrrolo[2,3-d]pyrimidine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRKIA (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).