2-acetylamino-benzothiazole-6-sulfonyl chloride | 139601-01-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-acetylamino-benzothiazole-6-sulfonyl chloride
• 英文别名: 2-Acetylamino-benzothiazol-6-sulfonylchlorid；2-Acetamidobenzo[d]thiazole-6-sulfonyl chloride；2-acetamido-1,3-benzothiazole-6-sulfonyl chloride
• CAS: 139601-01-7
• 化学式: C₉H₇ClN₂O₃S₂
• 分子量: 290.751
• InChiKey: LVMRJRSCWBXBRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-acetylamino-benzothiazole-6-sulfonyl chloride 在 盐酸 、 苯 作用下， 生成 6-(piperidine-1-sulfonyl)-1,3-benzothiazol-2-amine
  参考文献：
  名称：

  Wang; Chang, Journal of the Chinese Chemical Society, 1948, vol. 15, p. 220,221

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(1,3-苯并噻唑-2-基)乙酰胺 在 氯磺酸 作用下， 生成 2-acetylamino-benzothiazole-6-sulfonyl chloride
  参考文献：
  名称：

  Wang et al., Journal of the Chinese Chemical Society, 1948, vol. 15, p. 208,211

  摘要：

  DOI：

文献信息

• Indole Compounds, Method of Preparing Them and Uses Thereof
  申请人：BINET Jean

  公开号：US20080153816A1

  公开（公告）日：2008-06-26

  Indole compounds corresponding to the formula (I): as defined in the claims, pharmaceutically acceptable addition salts of such compounds, pharmaceutical compositions containing such compounds, the process for their preparation, and their use as pharmacologically active substances, especially in the treatment of hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, diabetes, endothelial dysfunction, cardiovascular disease, inflammatory disease and neurodegeneration.

  与公式（I）相对应的吲哚化合物，如权利要求中所定义的，这些化合物的药学上可接受的加盐物，含有这些化合物的药物组合物，其制备方法，以及它们作为药理活性物质的用途，特别是在治疗高三酰甘油血症、高脂血症、高胆固醇血症、糖尿病、内皮功能障碍、心血管疾病、炎症性疾病和神经退行性疾病方面。
• Pyrrolopyridine Compounds, Method of Making Them and Uses Thereof
  申请人：Boubia Benaissa

  公开号：US20080200495A1

  公开（公告）日：2008-08-21

  Pyrrolopyridine compounds corresponding to formula (I): as defined in the claims, pharmaceutically acceptable salts thereof, the process for preparing such compounds, pharmaceutical compositions containing such compounds, and their use as pharmacologically active substances, especially in the treatment of hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, diabetes, endothelial dysfunction, cardiovascular diseases, inflammatory diseases and neurodegenerative diseases.

  与公式（I）中定义的吡咯吡啶化合物相应的药用盐，制备这类化合物的方法，含有这类化合物的药物组合物，以及它们作为药理活性物质的用途，特别是在治疗高甘油三酯血症、高脂血症、高胆固醇血症、糖尿病、内皮功能障碍、心血管疾病、炎症性疾病和神经退行性疾病方面。
• Use of Pyrrolopyridine Compounds for Activating PPAR Receptors and Treatment of Conditions Involving Such Receptors
  申请人：Boubia Benaissa

  公开号：US20090239856A1

  公开（公告）日：2009-09-24

  A method of activating PPAR receptors in a subject, said method comprising administering to said subject an effective PPAR receptor activating amount of a pyrrolopyridine compound corresponding to formula (I): wherein R, R 1 , R 2 , R 3 , R 4 , X, Ar and n have defined meanings, or a pharmaceutically acceptable salt thereof, particularly as part of the treatment of a disorder or disease state selected from the group consisting of atherosclerosis, myocardial infarction, hypertension, and cerebral vascular disease.

  本发明涉及一种激活主体中PPAR受体的方法，该方法包括向该主体投与有效的PPAR受体激活量的与式(I)相对应的吡咯吡啶化合物，其中R、R1、R2、R3、R4、X、Ar和n具有定义的含义，或其药学上可接受的盐，特别用于治疗动脉粥样硬化、心肌梗死、高血压和脑血管疾病等疾病或病态。
• Method of Treating Conditions Involving PPAR-Receptors with Indole Compounds
  申请人：BINET Jean

  公开号：US20100286137A1

  公开（公告）日：2010-11-11

  Indole compounds corresponding to the formula (I): as defined in the claims, pharmaceutically acceptable addition salts of such compounds, pharmaceutical compositions containing such compounds, the process for their preparation, and their use as pharmacologically active substances, especially in the treatment of hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, diabetes, endothelial dysfunction, cardiovascular disease, inflammatory disease and neurodegeneration.

  本发明涉及化合物的吲哚类似物(I)的配方，这些化合物的药学上可接受的加盐物，含有这些化合物的制药组合物，其制备过程，以及作为药理活性物质的用途，特别是在高甘油三酯血症，高脂血症，高胆固醇血症，糖尿病，内皮功能障碍，心血管疾病，炎症性疾病和神经退行性疾病的治疗中。
• Organic materials having sulfonamido linked poly(oxyalkylene) moieties and their preparation
  申请人：MILLIKEN RESEARCH CORPORATION

  公开号：EP0445926A2

  公开（公告）日：1991-09-11

  The process for chemically modifying metal-free, organic material for improving one or more properties thereof such as water dispersibility, compatibility with other organics, or increased chemical reactivity, wherein the process includes providing material with from 1-6 sulfonylhalide groups or sulfonate ester groups or mixtures thereof, and contacting the material under sulfonamido forming conditions with one or more reactants containing one or more poly(oxyalkylene) moieties, each of the reactants having from 1 to 4 functional amine groups, and each of the poly(oxyalkylene) moieties being comprised of from about 4 to about 200 epoxide reactant residues at least about 50 mole percent of which residues contain 2-4 carbons.

  化学改性无金属有机材料以改善其一种或多种特性（如水分散性、与其他有机物的相容性或更高的化学反应活性）的工艺，其中该工艺包括提供具有 1-6 个磺酰卤基团或磺酸酯基团或其混合物的材料、在磺酰胺形成条件下，将材料与含有一个或多个聚（氧烷基）分子的一个或多个反应物接触，每个反应物具有 1 至 4 个官能胺基团，每个聚（氧烷基）分子由约 4 至约 200 个环氧化物反应物残基组成，其中至少约 50 摩尔%的残基含有 2-4 个碳。