3'-(N,N-Dimethyl-carbamoyl)-2'-hydroxy-5'-methyltetrazol-5-carboxanilid | 70977-54-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3'-(N,N-Dimethyl-carbamoyl)-2'-hydroxy-5'-methyltetrazol-5-carboxanilid
• 英文别名: 1(2)H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide；3'-(N,N-dimethylcarbamoyl)-2'-hydroxy-5'-methyltetrazole-5-carboxanilide；N-[3-(dimethylcarbamoyl)-2-hydroxy-5-methylphenyl]-2H-tetrazole-5-carboxamide
• CAS: 70977-54-7
• 化学式: C₁₂H₁₄N₆O₃
• 分子量: 290.282
• InChiKey: GBVDRUVQAMNNQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-benzyl-1H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide 在 三氯化铝 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以58%的产率得到3'-(N,N-Dimethyl-carbamoyl)-2'-hydroxy-5'-methyltetrazol-5-carboxanilid
  参考文献：
  名称：

  Synthesis and quantitative structure-activity relationships of antiallergic 2-hydroxy-N-(1H-tetrazol-5-yl)benzamides and N-(2-hydroxyphenyl)-1H-tetrazole-5-carboxamides

  摘要：

  The synthesis and antiallergic activity of a series of 2-hydroxy-N-1H-tetrazol-5-ylbenzamides and isomeric N-(2-hydroxyphenyl)-1H-tetrazole-5-carboxamides is described. A relationship between structure and intravenous antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) test has been established using a Hansch/Free-Wilson model and used to direct studies toward potent derivatives. The contribution of physicochemical properties to activity is discussed. One member of this series, N-(3-acetyl-5-fluoro-2-hydroxyphenyl)-1H-tetrazole-5-carboxamide (3f), which was selected for further evaluation, has an ID50 value of 0.16 mg/kg po and is 130 times more potent than disodium cromoglycate (DSCG) on intravenous administration.

  DOI：

  10.1021/jm00154a019

文献信息

• 2'Hydroxy tetrazole-5-carboxanilides and anti-allergic use thereof
  申请人：May & Baker Limited

  公开号：US04442115A1

  公开（公告）日：1984-04-10

  New tetrazole derivatives of the general formula: ##STR1## [wherein R.sup.1 represents a halogen atom, a straight- or branched-chain alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino, or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), a straight- or branched-chain alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl or alkanoylamino group containing from 2 to 6 carbon atoms, a cycloalkylcarbonyl group containing from 3 to 8 carbon atoms in the cycloalkyl moiety, or a hydroxy, formyl, nitro, trifluoromethyl, trifluoroacetyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl, benzyloxy, aralkanoyl or aroyl group, or a group of the formula: --CR.sup.2 .dbd.NOR.sup.3 II (wherein R.sup.2 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 5 carbon atoms, an aryl, aralkyl or trifluoromethyl group, or a cycloalkyl group containing from 3 to 8 carbon atoms, and R.sup.3 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 6 carbon atoms optionally substituted by a phenyl group, or represents an aryl group optionally substituted by one or more substituents selected from halogen atoms and straight- or branched-chain alkyl and alkoxy groups containing from 1 to 6 carbon atoms and hydroxy, trifluoromethyl and nitro groups), and m represents zero or an integer 1, 2 or 3, the substituents R.sup.1 being the same or different when m represents 2 or 3] possess pharmacological properties, in particular properties of value in the treatment of allergic conditions.

  新的四唑衍生物的一般化学式为：##STR1##[其中R.sup.1代表卤素原子，直链或支链烷基，烷氧基，烷硫基，烷基亚硫酰基，烷基磺酰基或烷基磺胺基，每个这样的基团含有1至6个碳原子，双烷基磺酰胺基，双烷基氨基或双烷基氨基甲酰基（其中两个烷基可能相同或不同，每个含有1至4个碳原子），直链或支链脂肪酰基，烷氧基羰基，烷氧基羰基氨基，烷基甲酰胺基或脂肪酰胺基含有2至6个碳原子，环烷基羰基含有3至8个碳原子的环烷基基团，或羟基，甲酰基，硝基，三氟甲基，三氟乙酰基，芳基，苄氧羰胺基，氨基，磺酰胺基，氰基，四唑-5-基，羧基，氨基甲酰基，苄氧基，芳基酰基或芳酰基，或式子：--CR.sup.2.dbd.NOR.sup.3 II（其中R.sup.2代表氢原子或含有1至5个碳原子的直链或支链烷基，芳基，芳基烷基或三氟甲基基团，或含有3至8个碳原子的环烷基基团，R.sup.3代表氢原子，或含有1至6个碳原子的直链或支链烷基基团，可选择地由苯基取代，或表示由一个或多个取代基选择的卤素原子和直链或支链烷基和烷氧基基团，含有1至6个碳原子和氢氧基，三氟甲基和硝基基团），m表示零或整数1、2或3，当m表示2或3时，取代基R.sup.1相同时或不同时]具有药理学性质，特别是在治疗过敏症状方面具有价值的性质。
• FORD, E.;KNOWLES, PH.;LUNT, E.;MARSHALL, S. M.;PENROSE, A. J.;RAMSDEN, A.+, J. MED. CHEM., 1986, 29, N 4, 538-549
  作者：FORD, E.、KNOWLES, PH.、LUNT, E.、MARSHALL, S. M.、PENROSE, A. J.、RAMSDEN, A.+

  DOI：——

  日期：——
• US4442115A
  申请人：——

  公开号：US4442115A

  公开（公告）日：1984-04-10
• Synthesis and quantitative structure-activity relationships of antiallergic 2-hydroxy-N-(1H-tetrazol-5-yl)benzamides and N-(2-hydroxyphenyl)-1H-tetrazole-5-carboxamides
  作者：Roger E. Ford、Phillip Knowles、Edward Lunt、Stuart M. Marshall、Audrey J. Penrose、Christopher A. Ramsden、Anthony J. H. Summers、Joyce L. Walker、Derek E. Wright

  DOI：10.1021/jm00154a019

  日期：1986.4

  The synthesis and antiallergic activity of a series of 2-hydroxy-N-1H-tetrazol-5-ylbenzamides and isomeric N-(2-hydroxyphenyl)-1H-tetrazole-5-carboxamides is described. A relationship between structure and intravenous antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) test has been established using a Hansch/Free-Wilson model and used to direct studies toward potent derivatives. The contribution of physicochemical properties to activity is discussed. One member of this series, N-(3-acetyl-5-fluoro-2-hydroxyphenyl)-1H-tetrazole-5-carboxamide (3f), which was selected for further evaluation, has an ID50 value of 0.16 mg/kg po and is 130 times more potent than disodium cromoglycate (DSCG) on intravenous administration.