3-methylamino-thiophene-2-carboxylic acid amide | 1023310-26-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 3-methylamino-thiophene-2-carboxylic acid amide
• 英文别名: 3-(methylamino)thiophene-2-carboxamide
• CAS: 1023310-26-0
• 化学式: C₆H₈N₂OS
• 分子量: 156.208
• InChiKey: RCDFIWBXWBVVSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  83.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-methylamino-thiophene-2-carboxylic acid amide 、 苯甲酰氯 在 氯仿 、 碳酸氢钠 、 magnesium sulfate 、 crude product 、 silica 、 二氯甲烷,丙烷-2-酮 作用下， 以 氯仿 为溶剂， 反应 1.5h， 生成 1-methyl-2-phenyl-1H-thieno[3,2-d]pyrimidine-4-one
  参考文献：
  名称：

  Fluorescent double stranded DNA binding dyes

  摘要：

  本发明揭示了一种荧光染料，包含苯并噻唑基团和嘧啶基团，由单甲烯桥连接，其特征在于（i）嘧啶的2位携带以C原子开头的取代基，（ii）嘧啶环的5-和6-位是进一步芳香环结构的一个不可分割的部分，例如以下所示：

  公开号：

  US08058431B2
• 作为产物：
  描述：

  1-methylthieno[3,2-d][1,3]oxazine-2,4-dione 在 ammonium hydroxide 、 盐酸 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 3-methylamino-thiophene-2-carboxylic acid amide
  参考文献：
  名称：

  [EN] DIACYLGLYCEROL KINASE (DGK) ALPHA INHIBITORS AND USES THEREOF
  [FR] INHIBITEURS DE DIACYLGLYCÉROL KINASE (DGK) ALPHA ET LEURS UTILISATIONS

  摘要：

  Provided are DGKalpha inhibitors and pharmaceutical compositions comprising said inhibitors. The compounds and compositions are useful for the treatment of a disease or disorder associated with DGKalpha.

  公开号：

  WO2023165525A1

文献信息

• [EN] THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS<br/>[FR] THIÉNOPYRIMIDINES EN TANT QU'INHIBITEURS DE LA KINASE CDC7
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2010101302A1

  公开（公告）日：2010-09-10

  The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.

  本发明涉及一种由式(I)表示的化合物，其中每个符号如规范中定义，或其盐，或其前药，用于预防或治疗癌症。
• Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists
  申请人：——

  公开号：US20010020024A1

  公开（公告）日：2001-09-06

  A compound of the following formula: 1 and the salts thereof, wherein A is hydrogen, halo, hydroxy, or the like; the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar 1 is optionally substituted phenyl or the like; Ar 2 is aryl or heteroaryl selected from phenyl, napththyl, pyridyl, and the like, the aryl or heteroaryl being optionally substituted; R 1 is hydrogen, hydroxy, C 1 -C 4 alkyl, or the like; and R 2 and R 3 are independently selected from optionally substituted C 1 -C 7 alkyl, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, and the like or R 2 and R 3 , together with the nitrogen atom to which they are attached, form an optionally substituted pyrrolidine, piperidine or morpholine ring. These compounds are useful as kappa agonists.

  以下化合物的化学式：1及其盐，其中A为氢，卤素，羟基或类似物；断线表示可选的双键，如果断线是双键，则A不存在；Ar1为可选的取代苯基或类似物；Ar2为苯基，萘基，吡啶基等的芳基或杂环芳基，芳基或杂环芳基可选取代基；R1为氢，羟基，C1-C4烷基或类似物；R2和R3分别选自可选的取代C1-C7烷基，C3-C6环烷基，C2-C6烯基，C2-C6炔基等，或者R2和R3与它们所连接的氮原子一起形成可选的取代吡咯烷，哌啶或吗啉环。这些化合物可用作kappa受体激动剂。
• Inhibitors Of Hepatitis C Virus Protease, And Compositions And Treatments Using The Same
  申请人：Collins Raymond Michael

  公开号：US20070249637A1

  公开（公告）日：2007-10-25

  The present invention provides compounds of formula (I), (II) or (IV), or pharmaceutically acceptable salts and solvates thereof, which are useful as inhibitors of the Hepatitis C virus (HCV) protease enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals, including humans. The present invention also provides pharmaceutical compositions comprising compounds of formula (I), (II) or (IV), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formulas (I), (II) and (IV).

  本发明提供了公式(I)、(II)或(IV)的化合物，以及其药学上可接受的盐和溶剂，这些化合物对丙型肝炎病毒(HCV)蛋白酶酶具有抑制作用，并且也可用于治疗HCV感染的哺乳动物，包括人类。本发明还提供了包含公式(I)、(II)或(IV)的化合物、其药学上可接受的盐和溶剂的制药组合物。此外，本发明还提供了中间体化合物和制备公式(I)、(II)和(IV)化合物的方法。
• FLUORESCENT DOUBLE STRANDED DNA BINDING DYES
  申请人：Josel Hans-Peter

  公开号：US20090275037A1

  公开（公告）日：2009-11-05

  The present invention is directed to a fluorescent dye comprising a benzothiazolium moiety and a pyrimidinium moiety connected by a mono-methine bridge, characterized in that (i) the 2-position of the pyrimidine carries a substituent which starts with a C-atom and (ii) the 5- and 6-positions of the pyrimidine ring are an integral part of a further aromatic ring structure.

  本发明涉及一种荧光染料，其包含一种苯并噻唑基团和一种嘧啶基团，由单甲烯桥连接，其特征在于（i）嘧啶的2位携带以C原子开头的取代基，（ii）嘧啶环的5和6位是另一芳香环结构的组成部分。
• NOVEL TRIAZINE COMPOUNDS
  申请人：Dugar Sundeep

  公开号：US20130303516A1

  公开（公告）日：2013-11-14

  The present invention relates to novel triazine compounds of formula (1), methods of their preparation, pharmaceutical compositions containing these compounds and the use of these compounds to treat proliferative disorders such as tumors and cancers and also other conditions and disorders related to or associated with dysregulation of PI3 Kinases, PI3 Kinase pathway, mTOR and/or the mTOR pathway.

  本发明涉及公式（1）的新型三嗪类化合物，其制备方法、含有这些化合物的药物组合物以及使用这些化合物治疗增殖性疾病，如肿瘤和癌症，以及与PI3激酶、PI3激酶途径、mTOR和/或mTOR途径失调相关或相关的其他状况和疾病。