3-[(2-Diethylamino-ethyl)-(3-hydroxy-propyl)-amino]-propan-1-ol | 42434-18-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-[(2-Diethylamino-ethyl)-(3-hydroxy-propyl)-amino]-propan-1-ol
• 英文别名: 3-[2-(Diethylamino)ethyl-(3-hydroxypropyl)amino]propan-1-ol
• CAS: 42434-18-4
• 化学式: C₁₂H₂₈N₂O₂
• 分子量: 232.367
• InChiKey: JOKMBONIEGNKBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-[(2-Diethylamino-ethyl)-(3-hydroxy-propyl)-amino]-propan-1-ol 、 甲基磺酰氯 以 乙腈 为溶剂， 生成 Methanesulfonic acid 3-[(2-diethylamino-ethyl)-(3-methanesulfonyloxy-propyl)-amino]-propyl ester
  参考文献：
  名称：

  Synthesis and Evaluation of the Anticancer Activity of a New Series of Methanesulfonates

  摘要：

  制备了九种新的氨基糖苷甲烷磺酸酯。 它们对吉田肉瘤、小鼠白血病L-1210和大鼠白血病DBLA-6的抗癌活性进行了评估。 从这些化合物中，3,3'-(吗啉基丙基亚氨基)二-1-丙醇、二甲烷磺酸酯(酯)、二盐酸盐(No.888)和3,3'-(二丁基氨基丙基亚氨基)二-1-丙醇、二甲烷磺酸酯(酯)、二盐酸盐(No.893)被证明非常活跃。 No.893在静脉注射系统对大鼠白血病DBLA-6(GV)的作用方面具有独特性。

  DOI：

  10.1248/cpb.21.1560
• 作为产物：
  描述：

  ethyl 3-[2-(diethylamino)ethyl-(3-ethoxy-3-oxopropyl)amino]propanoate 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 3-[(2-Diethylamino-ethyl)-(3-hydroxy-propyl)-amino]-propan-1-ol
  参考文献：
  名称：

  Synthesis and Evaluation of the Anticancer Activity of a New Series of Methanesulfonates

  摘要：

  制备了九种新的氨基糖苷甲烷磺酸酯。 它们对吉田肉瘤、小鼠白血病L-1210和大鼠白血病DBLA-6的抗癌活性进行了评估。 从这些化合物中，3,3'-(吗啉基丙基亚氨基)二-1-丙醇、二甲烷磺酸酯(酯)、二盐酸盐(No.888)和3,3'-(二丁基氨基丙基亚氨基)二-1-丙醇、二甲烷磺酸酯(酯)、二盐酸盐(No.893)被证明非常活跃。 No.893在静脉注射系统对大鼠白血病DBLA-6(GV)的作用方面具有独特性。

  DOI：

  10.1248/cpb.21.1560

文献信息

• CATALYST COMPOSITION FOR PRODUCTION OF POLYURETHANE RESIN AND METHOD FOR PRODUCING POLYURETHANE RESIN (AS AMENDED)
  申请人：Kometani Hiroyuki

  公开号：US20100130629A1

  公开（公告）日：2010-05-27

  Disclosed is a catalyst composition for polyurethane resin production which contains (A) triethylenediamine, (B) a specific polyisocyanurating catalyst and/or (C) a specific highly temperature-sensitive catalyst. By using this catalyst composition, a polyurethane resin can be molded with good curability, while suppressing initial reactivity. Consequently, a polyurethane resin having excellent moldability and fluidity can be produced with high productivity by using the catalyst composition. The thus-obtained polyurethane resin is suitably applicable to shoe soles. The component (B) is selected from the group consisting of alkali metal salts of carboxylic acids, quaternary ammonium compounds expressed as R 1 R 2 R 3 R 4 N + ,X − , N,N,N′-trimethylaminoethylethanolamine, and 2,4,6-tris(dimethylaminomethyl)phenol, while the component (C) is selected from the group consisting of triazole salts and benzotriazole salts of 1,8-diazabicyclo[5.4.0]undecene-7 or 1,5-diazabicyclo[4.3.0]nonene-5. The mixing ratio of the component (B) and/or the component (C) to the component (A) is from 2% by weight to 60% by weight.

  本发明涉及一种用于聚氨酯树脂生产的催化剂组合物，其包含（A）三乙二胺，（B）特定的聚异氰酸酯催化剂和/或（C）特定的高温敏感催化剂。通过使用这种催化剂组合物，可以制造具有良好可固化性的聚氨酯树脂，同时抑制初始反应性。因此，使用催化剂组合物可以生产具有出色的可塑性和流动性的聚氨酯树脂，并具有高生产率。因此制造的聚氨酯树脂适用于鞋底。组分（B）选自羧酸的碱金属盐、表示为R1R2R3R4N+，X−的季铵化合物、N，N，N′-三甲基氨基乙基乙醇胺和2,4,6-三（二甲胺甲基）苯酚组成的群，而组分（C）选自1,8-二氮杂双环[5.4.0]十一烯-7或1,5-二氮杂双环[4.3.0]壬烯-5的三唑盐和苯并三唑盐组成的群。组分（B）和/或组分（C）与组分（A）的混合比重为2重量％至60重量％。
• Catalyst composition for the production of a polyurethane resin, and method for producing a polyurethane resin
  申请人：Tosoh Corporation

  公开号：EP1092737A2

  公开（公告）日：2001-04-18

  A catalyst composition for the production of a polyurethane resin, which comprises an amine compound of the following formula (1): wherein each of R1 and R2 which are independent of each other, is a C1-4 alkyl group, such alkyl groups bonded to each other directly or via a nitrogen atom or an oxygen atom to form a ring structure, a dimethylaminopropyl group or a diethylaminopropyl group, and R3 is a C2-16 straight chain or branched chain alkylene group, and an amine compound of the following formula (2): wherein each of R4 and R5 which are independent of each other, is a C1-4 alkyl group, such alkyl groups bonded to each other directly or via a nitrogen atom or an oxygen atom to form a ring structure, a dimethylaminopropyl group or a diethylaminopropyl group, R6 is a C2-16 straight chain or branched chain alkylene group, R7 is a C2-3 straight chain or branched chain alkylene group, and n is an integer of from 0 to 2.

  一种用于生产聚氨酯树脂的催化剂组合物，它包括下式(1)的胺化合物： 其中相互独立的 R1 和 R2 均为 C1-4 烷基，此类烷基直接或通过氮原子或氧原子相互键合以形成环状结构、二甲基氨基丙基或二乙基氨基丙基，R3 为 C2-16 直链或支链亚烷基，以及下式（2）的胺化合物： R4 和 R5 均为 C1-4 烷基，此类烷基直接或通过氮原子或氧原子相互键合以形成环状结构、二甲基氨基丙基或二乙基氨基丙基，R3 为 C2-16 直链或支链亚烷基： 其中相互独立的 R4 和 R5 各为 C1-4 烷基，此类烷基直接或通过氮原子或氧原子相互键合以形成环状结构、二甲基氨基丙基或二乙基氨基丙基，R6 为 C2-16 直链或支链亚烷基，R7 为 C2-3 直链或支链亚烷基，n 为 0 至 2 的整数。
• CATALYST COMPOSITION FOR POLYURETHANE RESIN PRODUCTION AND METHOD FOR PRODUCING POLYURETHANE RESIN
  申请人：Tosoh Corporation

  公开号：EP2050775A1

  公开（公告）日：2009-04-22

  To provide a catalyst composition which is a catalyst composition not impairing the physical properties of a polyurethane resin and the storage stability of the starting material blend liquid and which is capable of producing a polyurethane resin excellent in curability and also excellent in moldability by suppressing the initial reactivity, with good productivity. A catalyst composition for production of a polyurethane resin, which comprises (A) triethylenediamine, and (B) a polyisocyanurating catalyst and/or (C) a highly temperature sensitive catalyst, wherein the polyisocyanurating catalyst (B) is one or more compounds selected from the group consisting of an alkali metal salt of a carboxylic acid, a quaternary ammonium salt compound of the following formula (1): wherein each of R1 to R3 is a C1-12 linear or branched, saturated or unsaturated hydrocarbon group, provided that any two among R1 to R3 may form a hetero ring via an oxygen atom or a nitrogen atom, R4 is a C1-18 alkyl group or an aromatic hydrocarbon group, and X is an organic acid group having an acid dissociation constant (pKa) of at most 4.8, N,N,N'-trimethylaminoethylethanolamine and 2,4,6-tris(dimethylaminomethyl)phenol; the highly temperature sensitive catalyst (C) is one or more compounds selected from the group consisting of a triazole salt of 1,8-diazabicyclo[5.4.0]undecene-7, a benzotriazole salt of 1,8-diazabicyclo[5.4.0]undecene-7, a triazole salt of 1,5-diazabicyclo[4.3.0]nonene-5, a benzotriazole salt of 1,5-diazabicyclo[4.3.0]nonene-5, a triazole salt of 1,8-diazabicyclo[5.3.0]decene-7 and a benzotriazole salt of 1,8-diazabicyclo[5.3.0]decene-7; and the blend ratio of the polyisocyanurating catalyst (B) and/or the highly temperature sensitive catalyst (C) to the triethylenediamine (A) is from 2 wt% to 60 wt%.

  提供一种催化剂组合物，该催化剂组合物不影响聚氨酯树脂的物理性质和起始原料混合液的贮存稳定性，并能通过抑制初始反应性生产出固化性优异、成型性优异的聚氨酯树脂，同时具有良好的生产率。 一种用于生产聚氨酯树脂的催化剂组合物，它包括(A)三乙二胺和(B)多异氰酸酯催化剂和/或(C)高温度敏感催化剂，其中多异氰酸酯催化剂(B)是从羧酸的碱金属盐、下式(1)的季铵盐化合物组成的组中选出的一种或多种化合物： 其中 R1 至 R3 各为 C1-12 直链或支链、饱和或不饱和烃基，但 R1 至 R3 中的任意两个可通过氧原子或氮原子形成杂环；R4 为 C1-18 烷基或芳香烃基；X 为有机酸基团，其酸解离常数（pKa）最多为 4。8, N,N,N'-trimethylaminoethylethanolamine 和 2,4,6-tris(dimethylaminomethyl)phenol; 高温度敏感催化剂 (C) 是一种或多种化合物，选自由 1,8-diazabicyclo[5.4.0]十一烯-7 的三唑盐、1,8-二氮杂双环[5.4.0]十一烯-7 的苯并三唑盐、1,5-二氮杂双环[4.3.0]壬烯-5 的三唑盐、1,5-二氮杂双环[4.3.0]壬烯-5 的苯并三唑盐、1,8-二氮杂双环[5.3.0]癸烯-7的三唑盐和1,8-二氮杂双环[5.3.0]癸烯-7的苯并三唑盐；以及聚异氰酸酯催化剂(B)和/或高温敏性催化剂(C)与三乙二胺(A)的混合比例为2 wt%至60 wt%。
• METHOD, APPARATUS AND CHEMICAL PRODUCTS FOR TREATING PETROLEUM EQUIPMENT
  申请人：FERRARA Marcello

  公开号：US20130270157A1

  公开（公告）日：2013-10-17

  The present invention provides a method, an apparatus and chemical products for treating petroleum equipment wherein a fluid is flowing, preferably of the hydrocarbon type, and wherein treating is performed by establishing a closed or semi-closed flow circulation loop, during the normal production operations of the equipment. The treatment can refer to the cleaning of equipment, to yield improvement as compared to normal run conditions and/or to a reduction of coke formation and/or to coke removal on catalysts.
• US6596663B1
  申请人：——

  公开号：US6596663B1

  公开（公告）日：2003-07-22