丙烯腈-13C3 | 202326-55-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 丙烯腈-13C3
• 英文名称: (1,2,3-13C)acrylonitrile
• 英文别名: acrylonitrile-¹³C₃；(1,2,3-13C3)Prop-2-enenitrile
• CAS: 202326-55-4
• 化学式: C₃H₃N
• 分子量: 56.0305
• InChiKey: NLHHRLWOUZZQLW-VMIGTVKRSA-N

物化性质

• 密度：
  0.850 g/mL at 25 °C
• 溶解度：
  可溶于氯仿（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  苄硫醇 、 丙烯腈-13C3 在 三甲基苯基氢氧化铵 作用下， 以 甲醇 、 乙醇 为溶剂， 以0.65 g的产率得到¹³C₃-benzylthiopropionitrile
  参考文献：
  名称：

  ESI-Q-TOF-MS determination of polyamines and related enzyme activity for elucidating cellular polyamine metabolism

  摘要：

  We developed a new procedure for the comprehensive analysis of metabolites and enzymes involved in polyamine metabolism pathways. The procedure utilizes stable isotope-labeled polyamines and directly and precisely determines labeled products from enzymatic reactions by ESI-Q-TOF-MS. The activity of different enzymes could be determined in essentially the same manner by suitably adjusting the reaction conditions for each individual enzyme. We applied the procedure to extracts of regenerating rat liver and analyzed the changes in polyaminemetabolizing enzymes and polyamine contents during recovery from partial hepatectomy. A general outline of polyamine metabolism and information of polyamine dynamics were obtained. This kind of comprehensive information would be valuable in unifying detailed but fragmentary information obtained through conventional analyses focusing on one or a few enzymes and on a limited aspect of polyamine metabolic pathway.

  DOI：

  10.1016/j.ab.2020.113831

文献信息

• ESI-Q-TOF-MS determination of polyamines and related enzyme activity for elucidating cellular polyamine metabolism
  作者：Shun-suke Moriya、Keijiro Samejima、Hideharu Taira、Kyoko Hiramatsu、Masao Kawakita

  DOI：10.1016/j.ab.2020.113831

  日期：2020.10

  We developed a new procedure for the comprehensive analysis of metabolites and enzymes involved in polyamine metabolism pathways. The procedure utilizes stable isotope-labeled polyamines and directly and precisely determines labeled products from enzymatic reactions by ESI-Q-TOF-MS. The activity of different enzymes could be determined in essentially the same manner by suitably adjusting the reaction conditions for each individual enzyme. We applied the procedure to extracts of regenerating rat liver and analyzed the changes in polyaminemetabolizing enzymes and polyamine contents during recovery from partial hepatectomy. A general outline of polyamine metabolism and information of polyamine dynamics were obtained. This kind of comprehensive information would be valuable in unifying detailed but fragmentary information obtained through conventional analyses focusing on one or a few enzymes and on a limited aspect of polyamine metabolic pathway.