3,6-Dichloro-4-methyl-benzene-1,2-diol | 57341-94-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3,6-Dichloro-4-methyl-benzene-1,2-diol
• 英文别名: 3,6-Dichloro-4-methylcatechol；3,6-dichloro-4-methylbenzene-1,2-diol
• CAS: 57341-94-3
• 化学式: C₇H₆Cl₂O₂
• 分子量: 193.029
• InChiKey: CHQNQSPYETYIHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-Hydroxy-3,6,6-trichlor-4-methylcyclohex-2-en-1-on 在 lithium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 3,6-Dichloro-4-methyl-benzene-1,2-diol
  参考文献：
  名称：

  取代焦儿茶酚的简便合成

  摘要：

  发现取代的邻苯二酚衍生物是通过多氯环己烷-1,2-二酮与碳酸锂在 DMF 中的反应形成的。

  DOI：

  10.1246/bcsj.48.2215

文献信息

• CEPHEM COMPOUND HAVING PYRIDINIUM GROUP
  申请人：Nishitani Yasuhiro

  公开号：US20140114060A1

  公开（公告）日：2014-04-24

  The present invention provides a novel compound which has a broad antibacterial spectrum and particularly exhibits a high antibacterial activity on β-lactamase-producing gram-negative bacteria. Specifically provided are: a compound represented by formula (I) wherein the meaning of each symbol is as defined in the description, an amino-group-protected form of a type of the compound which has the amino group on a ring in a position-7 side chain, or a pharmaceutically acceptable salt of the compound or the amino-group-protected form; and a pharmaceutical composition containing the compound, the amino-group-protected form or the pharmaceutically acceptable salt.

  本发明提供了一种新型化合物，具有广泛的抗菌谱，特别对产β-内酰胺酶的革兰氏阴性细菌表现出高抗菌活性。具体提供的是：一种由式(I)表示的化合物，其中每个符号的含义如描述中定义的那样，一种在环上具有氨基团的化合物的保护形式，该化合物在位置-7侧链上具有氨基团，或者化合物或氨基团保护形式的药用可接受盐；以及含有该化合物、氨基团保护形式或药用可接受盐的药物组合物。
• 2-SUBSTITUTED CEPHEM COMPOUNDS
  申请人：GLAXO GROUP LIMITED

  公开号：US20150299223A1

  公开（公告）日：2015-10-22

  The present invention relates to 2-substituted cephem compounds of Formula (I) having a quaternary ammonium group on the 3-side chain, preferably together with a cathechol group, or pharmaceutically acceptable salts thereof, which exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, corresponding pharmaceutical compositions, methods of making, treatment methods for bacterial infections or uses thereof.

  本发明涉及具有第3侧链上季铵基团的2-取代头孢菌素化合物（I）, 与儿茶酚基团一起更佳，或其药学上可接受的盐，对包括革兰氏阴性菌和/或革兰氏阳性菌在内的多种细菌具有强效的抗微生物谱，相应的制药组合物，制备方法，治疗细菌感染的方法或其用途。
• Process for the treatment of plastic profiles
  申请人：Bayer MaterialScience AG

  公开号：EP1739119A1

  公开（公告）日：2007-01-03

  A process for treatment of the plastic profiles which is characterized in that the plastic profile, after being extruded and calibrated, is passed through a bath containing at least one additive.

  一种处理塑料型材的工艺，其特征在于塑料型材在经过挤压和校准后，要通过一个含有至少一种添加剂的浴槽。
• NOVEL CEPHEM COMPOUND HAVING CATECHOL OR PSEUDO-CATECHOL STRUCTURE
  申请人：Shionogi & Co., Ltd.

  公开号：EP2703406A1

  公开（公告）日：2014-03-05

  The present invention provides a novel compound which has a wide antimicrobial spectrum, and in particular exhibits potent antimicrobial activity against beta-lactamase producing Gram negative bacteria. Specifically, the present invention provides a compound of the formula (I): wherein each symbol is as defined in the specification, or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.

  本发明提供了一种新型化合物，它具有广泛的抗菌谱，特别是对β-内酰胺酶产生的革兰氏阴性菌具有强效抗菌活性。具体地说，本发明提供了一种式（I）化合物： 其中各符号如说明书中所定义、 或当氨基存在于 7 侧链的环上时的氨基保护化合物，或其药学上可接受的盐，以及由其组成的药物组合物。
• Organic photochromic compositions of improved kinetic performance
  申请人：——

  公开号：US20030045612A1

  公开（公告）日：2003-03-06

  Described are imbibition compositions that incorporate kinetic enhancing additive(s) into photochromic polymeric host material. Kinetic enhancing additives include organic polyol(s), epoxy-containing compound(s) or a mixture thereof that improves the performance of organic photochromic compounds in the polymeric host as determined in the Photochromic Performance Test. Also described is a process for incorporating kinetic enhancing additives into polymeric substrates prior to, after and/or with organic photochromic compounds and the resulting photochromic articles produced by such a process.

  所述的浸泡组合物在光致变色聚合主材料中加入了动力学增强添加剂。动力学增强添加剂包括有机多元醇、含环氧化合物或它们的混合物，这些添加剂可改善聚合物主材料中有机光致变色化合物的性能，如在光致变色性能测试中确定的那样。此外，还描述了一种在有机光致变色化合物之前、之后和/或与有机光致变色化合物一起将动力学增强添加剂加入聚合物基质中的工艺，以及通过这种工艺生产的光致变色物品。