ethyl 1,2,5,6,7,8-hexahydro-2-oxo-1,6-naphthyridine-3-carboxylate | 156364-00-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: ethyl 1,2,5,6,7,8-hexahydro-2-oxo-1,6-naphthyridine-3-carboxylate
• 英文别名: Ethyl 2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylate；ethyl 2-oxo-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carboxylate
• CAS: 156364-00-0
• 化学式: C₁₁H₁₄N₂O₃
• 分子量: 222.244
• InChiKey: MWGDCJFCBGSBGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cyclopropylmethyl 4-nitrophenyl carbonate 、 ethyl 1,2,5,6,7,8-hexahydro-2-oxo-1,6-naphthyridine-3-carboxylate 在 碳酸氢钠 作用下， 以 四氢呋喃 、 水 为溶剂， 以72 %的产率得到6-cyclopropylmethyl 3-ethyl 2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3,6-dicarboxylate
  参考文献：
  名称：

  3-(SULPHONYL OR SULFONIMIDOYL)PROP-2-EN-1-YL]-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE DERIVATIVES

  摘要：

  The present invention relates to 3-(sulphonyl or sulfonimidoyl)prop-2-en-1-yl]- 2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having the formula: or the pharmaceutical acceptable salt thereof. The present invention further relates to the compound according to the invention for use as a medicament and also for use in the treatment of cancer. The present invention further relates to a method for inhibiting Met1-linked ubiquitination. The present invention also relates to a pharmaceutical composition comprising the compound of the present invention.

  公开号：

  WO2023249490A1

文献信息

• 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
  申请人：Ashton T Wallace

  公开号：US20060074087A1

  公开（公告）日：2006-04-06

  The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及3-氨基-4-苯基丁酸衍生物，它们是二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂，可用于治疗或预防二肽基肽酶-IV酶涉及的疾病，如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗二肽基肽酶-IV酶涉及的这些疾病中使用这些化合物和组合物。
• 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
  申请人：Merck & Co., Inc.

  公开号：EP1592689A2

  公开（公告）日：2005-11-09
• EP1592689A4
  申请人：——

  公开号：EP1592689A4

  公开（公告）日：2008-12-24
• US5424433A
  申请人：——

  公开号：US5424433A

  公开（公告）日：1995-06-13
• US7388019B2
  申请人：——

  公开号：US7388019B2

  公开（公告）日：2008-06-17