5,5,7-trimethyl-1,4-diazacycloheptane | 226949-60-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5,5,7-trimethyl-1,4-diazacycloheptane
• 英文别名: (7R)-5,5,7-trimethyl-1,4-diazepane
• CAS: 226949-60-6
• 化学式: C₈H₁₈N₂
• 分子量: 142.244
• InChiKey: HJTAHWRHJPFFTK-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dichlorobis(dimethyl sulfoxide)platinum(II) 、 5,5,7-trimethyl-1,4-diazacycloheptane 在 LiCl 作用下， 以 甲醇 为溶剂， 以73%的产率得到
  参考文献：
  名称：

  The resolution of 5,5,7-trimethyl-1,4-diazacycloheptane: coordination to platinum(II), crystal structure of the dichloroplatinum(II) complex and HPLC separation of the [Pt(GpG)(tmdz)] adducts

  摘要：

  The resolution of the cyclic diamine tmdz (tmdz=5,5,7-trimethyl-1,4-diazaeycloheptane) is described. The absolute configuration was determined by preparation and crystal structure analysis of [PtCl2(R-tmdz)] by X-ray diffraction methods. Each enantiomer reacts with d(GpG) to form two isomers that were readily separated by HPLC. Significant stereoselectivity was observed in the reaction of the S enantiomer with d(GpG) but not in the reaction of the R enantiomer. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0277-5387(98)00390-8