N-formyl-dioncopeltine A | 135626-76-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-formyl-dioncopeltine A
• 英文别名: (1R,3R)-8-hydroxy-7-[5-hydroxy-2-(hydroxymethyl)-4-methoxynaphthalen-1-yl]-1,3-dimethyl-3,4-dihydro-1H-isoquinoline-2-carbaldehyde
• CAS: 135626-76-5
• 化学式: C₂₄H₂₅NO₅
• 分子量: 407.466
• InChiKey: PQMOHKOWHNZBDY-ZIAGYGMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  90.2
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-formyl-dioncopeltine A 在 PTC 盐酸 、 氢氧化钾 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 5.0h， 生成 8O,5'O-dimethyl-dioncopeltine A
  参考文献：
  名称：

  Dioncopeltine A and dioncolactone A: Alkaloids from Triphyophyllum peltatum

  摘要：

  The isolation of two novel alkaloids from Triphyophyllum peltatum is described. The complete stereostructure of dioncopeltine A, which is closely related to dioncophylline A, is established by spectroscopic, chiroptical, and degradative methods, and is furthermore confirmed by its transformation to O-methyl-dioncopophylline A, as well as by X-ray crystallography. Dioncolactone A, which can be transformed into dioncopeltine A by reductive ring-opening, is the first naturally occurring representative of this novel type of 'axially prostereogenic' biaryl alkaloids.

  DOI：

  10.1016/0031-9422(91)84235-k
• 作为产物：
  描述：

  'dioncolactone A' 在 lithium aluminium tetrahydride 、 甲酸 作用下， 以 四氢呋喃 为溶剂， 反应 26.0h， 生成 N-formyl-dioncopeltine A
  参考文献：
  名称：

  Dioncopeltine A and dioncolactone A: Alkaloids from Triphyophyllum peltatum

  摘要：

  The isolation of two novel alkaloids from Triphyophyllum peltatum is described. The complete stereostructure of dioncopeltine A, which is closely related to dioncophylline A, is established by spectroscopic, chiroptical, and degradative methods, and is furthermore confirmed by its transformation to O-methyl-dioncopophylline A, as well as by X-ray crystallography. Dioncolactone A, which can be transformed into dioncopeltine A by reductive ring-opening, is the first naturally occurring representative of this novel type of 'axially prostereogenic' biaryl alkaloids.

  DOI：

  10.1016/0031-9422(91)84235-k

文献信息

• BRINGMANN, GERHARD;RUBENACKER, MARTIN;VOGT, PETER;BUSSE, HOLGER;AKE, ASSI+, PHYTOCHEMISTRY, 30,(1991) N, C. 1691-1696
  作者：BRINGMANN, GERHARD、RUBENACKER, MARTIN、VOGT, PETER、BUSSE, HOLGER、AKE, ASSI+

  DOI：——

  日期：——