1,7-dihydro-3,5-dimethylbenzo<1,2-c:5,4-c'>dipyrazole | 115705-36-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1,7-dihydro-3,5-dimethylbenzo<1,2-c:5,4-c'>dipyrazole
• 英文别名: MDL 26020；3,5-Dimethyl-1,7-dihydro-benzo[1,2-c;5,4-c'']dipyrazole；3,5-dimethyl-1,6-dihydropyrazolo[4,3-f]indazole
• CAS: 115705-36-7
• 化学式: C₁₀H₁₀N₄
• 分子量: 186.216
• InChiKey: UXLCQXLOUGZAPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  57.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,7-dihydro-3,5-dimethylbenzo<1,2-c:5,4-c'>dipyrazole 在 硝酸 作用下， 以 硫酸 为溶剂， 反应 0.17h， 以89%的产率得到1,7-dihydro-3,5-dimethyl-8-nitrobenzo<1,2-c:5,4-c'>dipyrazole
  参考文献：
  名称：

  Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists

  摘要：

  3,5-Dimethylbenzo[1,2-c:5,4-c']dipyrazoles, optionally substituted in the 1-, 7-, and 8-positions, were synthesized from resorcinols. These compounds display affinity for adenosine A1 (rat brain) and A2 (human platelet) receptors. In addition, these compounds reverse contractions of guinea pig tracheal cylindrical segments induced by potassium chloride, histamine, acetylcholine, and 5-hydroxytryptamine, as well as reverse bronchospasm induced by aerosolized histamine in the conscious guinea pig.

  DOI：

  10.1021/jm00118a032
• 作为产物：
  描述：

  1,1'-(4,6-二羟基苯)二乙酮 在 一水合肼 作用下， 以 乙二醇甲醚 为溶剂， 反应 14.0h， 以90%的产率得到1,7-dihydro-3,5-dimethylbenzo<1,2-c:5,4-c'>dipyrazole
  参考文献：
  名称：

  Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists

  摘要：

  3,5-Dimethylbenzo[1,2-c:5,4-c']dipyrazoles, optionally substituted in the 1-, 7-, and 8-positions, were synthesized from resorcinols. These compounds display affinity for adenosine A1 (rat brain) and A2 (human platelet) receptors. In addition, these compounds reverse contractions of guinea pig tracheal cylindrical segments induced by potassium chloride, histamine, acetylcholine, and 5-hydroxytryptamine, as well as reverse bronchospasm induced by aerosolized histamine in the conscious guinea pig.

  DOI：

  10.1021/jm00118a032

文献信息

• PEET, NORTON P.;DICKERSON, GEORGE A.;ABDALLAH, ABDULMINIUM H.;DALY, JOHN +, J. MED. CHEM., 31,(1988) N 10, C. 2034-2039
  作者：PEET, NORTON P.、DICKERSON, GEORGE A.、ABDALLAH, ABDULMINIUM H.、DALY, JOHN +

  DOI：——

  日期：——
• [EN] ORGANIC LIGHT-EMITTING COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME<br/>[FR] COMPOSÉ ÉLECTROLUMINESCENT ORGANIQUE , ET DISPOSITIF ÉLECTROLUMINESCENT ORGANIQUE UTILISANT LE COMPOSÉ<br/>[KO] 유기발광 화합물 및 이를 이용한 유기 전계 발광 소자
  申请人：DOOSAN CORP

  公开号：WO2015099479A1

  公开（公告）日：2015-07-02

  본 발명은 발광능, 정공 수송능, 전자 수송능 등이 우수한 신규의 유기발광 화합물 및 상기 화합물을 하나 이상의 유기물층에 포함함으로써 발광효율, 구동 전압, 수명 등의 특성이 향상된 유기 전계 발광 소자에 관한 것이다.
• Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists
  作者：Norton P. Peet、George A. Dickerson、Abdulminium H. Abdallah、John W. Daly、Dieter Ukena

  DOI：10.1021/jm00118a032

  日期：1988.10

  3,5-Dimethylbenzo[1,2-c:5,4-c']dipyrazoles, optionally substituted in the 1-, 7-, and 8-positions, were synthesized from resorcinols. These compounds display affinity for adenosine A1 (rat brain) and A2 (human platelet) receptors. In addition, these compounds reverse contractions of guinea pig tracheal cylindrical segments induced by potassium chloride, histamine, acetylcholine, and 5-hydroxytryptamine, as well as reverse bronchospasm induced by aerosolized histamine in the conscious guinea pig.