6-methyl-1H,3H-thiazolo[4,3-c][1,4]thiazine-5,8-dione | 80142-33-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 6-methyl-1H,3H-thiazolo[4,3-c][1,4]thiazine-5,8-dione
• 英文别名: 6-methyl-3,8a-dihydro-1H-[1,3]thiazolo[4,3-c][1,4]thiazine-5,8-dione
• CAS: 80142-33-2
• 化学式: C₇H₉NO₂S₂
• 分子量: 203.286
• InChiKey: QTWHVXCQSZHINS-UHFFFAOYSA-N

物化性质

• 沸点：
  453.4±45.0 °C(Predicted)
• 密度：
  1.48±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  88
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(2-Mercaptopropanoyl)-thiazolidine-4-carboxylic acid 在 PPA 作用下， 反应 4.0h， 以41.9%的产率得到6-methyl-1H,3H-thiazolo[4,3-c][1,4]thiazine-5,8-dione
  参考文献：
  名称：

  血管紧张素转换酶抑制剂：具有降压活性的新型口服活性1,4-噻嗪-2,5-二酮，1,4-噻嗪-2,5-二酮和1,4-苯并噻嗪-2,5-二酮。

  摘要：

  一系列1,4-噻嗪-2,5-二酮，1,4-噻嗪-2,5-二酮和1,4-苯并硫氮杂-2,5-二酮的制备及其抑菌活性检查了体内和体外的血管紧张素转换酶（ACE）。这些化合物被假定为前药，因为它们在与大鼠血浆一起温育或经0.1 N HCl水溶液或磷酸盐缓冲液（pH 7.4）处理时会发生快速的开环反应，以产生相应的无生物活性的SH化合物。噻嗪类23-25和30在向大鼠口服给药时是ACE的有效抑制剂，其效力与卡托普利（1）相当。大鼠中最活跃的噻嗪类化合物分别为42和45。在所研究的苯并硫氮平中，22a在有意识的正常血压大鼠中抑制ACE的活性最高，ID50 = 0.15 mg / kg，po。

  DOI：

  10.1021/jm00155a032

文献信息

• Antihypertensive 1,4-thiazepine-ones, 1,4-thiazonine-ones, and method of
  申请人：USV Pharmaceutical Corporation

  公开号：US04287203A1

  公开（公告）日：1981-09-01

  Antihypertensive compounds of the structure ##STR1## wherein: n is an integer from 0 to 2 inclusive, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are independently hydrogen, alkyl having from 1 to 6 carbon atoms, alkenyl having from 2 to 6 carbon atoms, alkynyl having from 2 to 6 carbon atoms, cycloalkyl having from 3 to 16 carbon atoms, phenyl, benzyl, tolyl, naphthyl, phenethyl, indanyl, tetrahydronaphthyl, decanydronaphthyl, pyridyl, quinolyl, pyrrolidyl, pyrrolyl, morpholinyl, thiomorpholinyl, furyl, furfuryl, tetrahydrofurfuryl, benzimidazole, thienyl, imidolyl, or tetrahydroindolyl, and where the R.sub.1 to R.sub.7 groups are alkyl, said groups carrying a substituent selected from hydroxy, alkoxy, amino, carboxy, or carbalkoxy, the alkyl group in alkoxy and carbalkoxy having from 1 to 6 carbon atoms, or R.sub.2 taken together with R.sub.3 and the carbons to which they are attached is tetrahydronaphthyl or phenyl, and when phenyl R.sub.1 and R.sub.4 are absent, or R.sub.6 and R.sub.7 taken together with the carbon to which R.sub.6 is attached and the nitrogen to which R.sub.7 is attached form a heterocycle selected from pyrrolidyl, thiazolidine, tetrahydro-isoquinoline, thiomorpholine, or 2,2,5,5-tetramethylthiazolidinie, and Y is .dbd.O, .dbd.S, .dbd.NR.sub.1, .dbd.NOR.sub.1 or .dbd.N--NH.sub.2, R.sub.1 being the same as defined above.

  结构为##STR1##的降压化合物，其中：n是从0到2的整数，包括R.sub.1、R.sub.2、R.sub.3、R.sub.4、R.sub.5、R.sub.6和R.sub.7独立地为氢、具有1至6个碳原子的烷基、具有2至6个碳原子的烯基、具有2至6个碳原子的炔基、具有3至16个碳原子的环烷基、苯基、苄基、甲苯基、萘基、苯乙基、茚基、四氢萘基、十氢萘基、吡啶基、喹啉基、吡咯啉基、吡咯基、吗啉基、硫代吗啉基、呋喃基、呋喃基、四氢呋喃基、苯并咪唑基、噻吩基、咪唑基或四氢吲啶基，且R.sub.1到R.sub.7基团为烷基时，该基团携带从羟基、烷氧基、氨基、羧基或羰基中选择的取代基，烷氧基和羰基中的烷基基团具有1至6个碳原子，或者R.sub.2与R.sub.3及它们连接的碳一起形成四氢萘基或苯基，当苯基R.sub.1和R.sub.4缺失时，或者R.sub.6和R.sub.7与R.sub.6连接的碳和R.sub.7连接的氮一起形成从吡咯基、噻唑啉、四氢异喹啉、硫代吗啉或2,2,5,5-四甲基噻唑啉中选择的杂环，Y为.dbd.O、.dbd.S、.dbd.NR.sub.1、.dbd.NOR.sub.1或.dbd.N--NH.sub.2，其中R.sub.1与上述定义相同。
• Antihypertensive lactams
  申请人：——

  公开号：US04766210A1

  公开（公告）日：1988-08-23

  Antihypertensive compounds of the structure ##STR1## wherein: n is an integer from 0 to 2 inclusive, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are independently hydrogen, alkyl having from 1 to 6 carbon atoms, alkenyl having from 2 to 6 carbon atoms, alkynyl having from 2 to 6 carbon atoms, cycloalkyl having from 3 to 16 carbon atoms, phenyl, benzyl, tolyl, naphthyl, phenethyl, indanyl, tetrahydronaphthyl, decahydronaphthyl, pyridyl, quinolyl, pyrrolidyl, pyrrolyl, morpholinyl, thiomorpholinyl, furyl, furfuryl, tetrahydrofurfuryl, benzimidazole, thienyl, imidolyl, or tetrahydroindolyl, and where the R.sub.1 to R.sub.7 groups are alkyl, said groups carrying a substituent selected from hydroxy, alkoxy, amino, carboxy, or carbalkoxy, the alkyl group in alkoxy and carbalkoxy having from 1 to 6 carbon atoms, or R.sub.2 taken together with R.sub.3 and the carbons to which they are attached is tetrahydronapthyl or phenyl, and when phenyl R.sub.1 and R.sub.4 are absent, or R.sub.6 and R.sub.7 taken together with the carbon to which R.sub.6 is attached and the nitrogen to which R.sub.7 is attached form a heterocycle selected from pyrrolidyl, thiazolidine, tetrahydro-isoquinoline, thiomorpholine, or 2,2,5,5-tetramethylthiazolidinie, and Y is .dbd.O, .dbd.S, .dbd.NR.sub.1, .dbd.NOR.sub.1 or .dbd.N--NH.sub.2, R.sub.1 being the same as defined above.

  结构式为##STR1##的降压化合物，其中：n是0至2的整数，R.sub.1、R.sub.2、R.sub.3、R.sub.4、R.sub.5、R.sub.6和R.sub.7独立地为氢、碳数为1到6的烷基、碳数为2到6的烯基、碳数为2到6的炔基、碳数为3到16的环烷基、苯基、苄基、甲苯基、萘基、苯乙基、茚基、四氢萘基、十氢萘基、吡啶基、喹啉基、吡咯烷基、吡咯基、吗啉基、硫代吗啉基、呋喃基、呋喃甲基、四氢呋喃基、苯并咪唑基、噻吩基、咪唑基或四氢吲哚基，其中R.sub.1至R.sub.7基为烷基，所述基带有从羟基、烷氧基、氨基、羧基或羧烷氧基中选择的取代基，烷氧基和羧烷氧基中的烷基含有1到6个碳原子，或R.sub.2与R.sub.3及它们所连接的碳一起取代为四氢萘基或苯基，当苯基R.sub.1和R.sub.4不存在时，或R.sub.6和R.sub.7与R.sub.6所连接的碳和R.sub.7所连接的氮一起形成从吡咯基、噻唑环、四氢异喹啉、硫代吗啉或2,2,5,5-四甲基噻唑环中选择的杂环，且Y为.dbd.O、.dbd.S、.dbd.NR.sub.1、.dbd.NOR.sub.1或.dbd.N--NH.sub.2，其中R.sub.1与上述定义相同。
• SKILES, J. W.;SUH, J. T.;WILLIAMS, B. E.;MENARD, P. R.;BARTON, J. N.;LOEV+, J. MED. CHEM., 1986, 29, N 5, 784-796
  作者：SKILES, J. W.、SUH, J. T.、WILLIAMS, B. E.、MENARD, P. R.、BARTON, J. N.、LOEV+

  DOI：——

  日期：——
• US4287203A
  申请人：——

  公开号：US4287203A

  公开（公告）日：1981-09-01
• US4766210A
  申请人：——

  公开号：US4766210A

  公开（公告）日：1988-08-23