1-Ethylcyclopentancarbonitril | 49826-26-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Ethylcyclopentancarbonitril
• 英文别名: 1-Ethylcyclopentacarbonitrile；1-Ethylcyclopentane-1-carbonitrile
• CAS: 49826-26-8
• 化学式: C₈H₁₃N
• mdl: MFCD20882675
• 分子量: 123.198
• InChiKey: BKMKLODHNSECBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6-Chloro-2-ethyl-hexanenitrile 在 lithium diethylamide 作用下， 以 六甲基磷酰三胺 为溶剂， 生成 1-Ethylcyclopentancarbonitril
  参考文献：
  名称：

  新丁腈

  摘要：

  HMPT中的二乙氨基锂已用于制备和环化ω-卤代腈。环丁烷衍生物很容易从δ-氯腈中以高收率获得。

  DOI：

  10.1016/s0022-328x(00)86576-6

文献信息

• FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS
  申请人：Corkey Britton

  公开号：US20110021521A1

  公开（公告）日：2011-01-27

  The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W 1 , W 2 , W 3 , R 1 , Q, X 1 , X 2 and X 3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

  本发明涉及一类钠通道抑制剂化合物，以及它们在治疗各种疾病状态中的应用，包括心血管疾病和糖尿病。具体实施例中，该化合物的结构由下式给出：其中W1、W2、W3、R1、Q、X1、X2和X3如本文所述，以及制备和使用该化合物的方法，以及含有该化合物的药物组合物。
• Trimethylsilyl cyanide promoted cyanation of tertiary alkyl chlorides and other SN1 active compounds
  作者：Manfred T. Reetz、Ioannis Chatziiosifidis、Hermann Künzer、Hans Müller-Starke

  DOI：10.1016/s0040-4020(01)88594-x

  日期：1983.1

  Tertiary chlorides are readily cyanated in a one-pot procedure using trimethylsilyl cyanide in the presence of SnCl4. The mechanism of this novel and synthetically useful reaction involves initial isonitrile formation followed by rearrangement to the tertiary nitrile. Other SN1 active componds also undergo smooth cyanation.

  在存在SnCl 4的情况下，使用三甲基甲硅烷基氰化物可以在一锅法中轻易地将氯化叔氰化。这种新颖的，合成上有用的反应的机理包括最初形成异腈，然后重排成叔腈。其他s Ñ 1活性componds也经历平滑氰化。
• AMIDE COMPOUND AND USE THEREOF
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2151431A1

  公开（公告）日：2010-02-10

  Disclosed is an amide compound represented by the formula (1) below, which has excellent plant disease controlling activity. In the formula, X1 represents a fluorine atom or a methoxy group; X2 represents a chlorine atom, a bromine atom, an iodine atom, a C1-C4 alkyl group or the like; Z represents an oxygen atom or a sulfur atom; and A represents an A1-CR11R12R13 group or A2-Cy group, wherein A1 and A2 each represents a single bond or the like, R11 and R12 independently represent a C1-C4 alkyl group, R13 represents H, a C1-C4 alkyl group or the like, and Cy represents a C3-C6 cycloalkyl group or the like.

  本发明公开了一种酰胺化合物，其化学式如下（1），具有出色的植物病害控制活性。在该式中，X1代表氟原子或甲氧基；X2代表氯原子、溴原子、碘原子、C1-C4烷基或类似物；Z代表氧原子或硫原子；A代表A1-CR11R12R13基团或A2-Cy基团，其中A1和A2各代表单键或类似物，R11和R12分别独立地代表C1-C4烷基，R13代表H、C1-C4烷基或类似物，Cy代表C3-C6环烷基或类似物。
• AMIDE COMPOUND AND METHOD FOR CONTROLLING PLANT DISEASE USING THE SAME
  申请人：Komori Takashi

  公开号：US20100137376A1

  公开（公告）日：2010-06-03

  Disclosed is a plant disease control agent containing an amide compound represented by formula (1) below which has an excellent plant disease controlling effect as an active ingredient. (In the formula, X 1 , X 2 , Z 1 and E 1 are as defined in the description.)

  公开了一种植物病害控制剂，其包含一种酰胺化合物，该化合物用以下式（1）表示，作为活性成分具有优异的植物病害控制效果。（在式中，X1、X2、Z1和E1如说明书中所定义。）
• PLANT DISEASE CONTROL AGENT, AND PLANT DISEASE CONTROL METHOD
  申请人：Komori Takashi

  公开号：US20100137445A1

  公开（公告）日：2010-06-03

  Disclosed is a plant disease control agent comprising an amide compound represented by the formula (1) as an active ingredient. wherein X 1 represents a fluorine atom or a methoxy group; X 2 represents a hydrogen atom, a halogen atom, a C 1 -C 4 alkyl group, a C 2 -C 4 alkenyl group, a C 1 -C 4 haloalkyl group, a C 1 -C 4 alkoxy group, a C 1 -C 4 alkylthio group, a C 1 -C 4 hydroxyalkyl group and so on; Z 1 represents an oxygen atom or a sulfur atom; A 1 represents a single bond, —CH 2 — and so on; and G 1 represents a group CR 6 R 7 R 8 , a C 3-6 cycloalkyl group and so on.

  本发明公开了一种植物病害控制剂，其包含以式（1）表示的酰胺化合物作为活性成分。其中，X1代表氟原子或甲氧基；X2代表氢原子、卤素原子、C1-C4烷基、C2-C4烯基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4烷硫基、C1-C4羟基烷基等；Z1代表氧原子或硫原子；A1代表单键、—CH2—等；G1代表CR6R7R8基团、C3-6环烷基等。