[1,6]萘啶-5-甲酸 | 74048-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: [1,6]萘啶-5-甲酸
• 英文名称: 1,6-Naphthyridin-5-carbonsaeure
• 英文别名: [1,6]naphthyridine-5-carboxylic acid；1,6-Naphthyridine-5-carboxylic acid
• CAS: 74048-24-1
• 化学式: C₉H₆N₂O₂
• mdl: MFCD06762718
• 分子量: 174.159
• InChiKey: GZZARNGHJBDZPR-UHFFFAOYSA-N

物化性质

• 熔点：
  204-205 °C (decomp)
• 沸点：
  428.0±25.0 °C(Predicted)
• 密度：
  1.421±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.1
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride 、 [1,6]萘啶-5-甲酸 在 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-[1-(1,6-naphthyridin-5-ylcarbonyl)piperidin-4-yl]-2,4-dihydro-3H-pyrazol-3-one 、 crude product 、 silica gel 、 methanol-dichloromethane 作用下， 生成 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-[1-(1,6-naphthyridin-5-ylcarbonyl)piperidin-4-yl]-2,4-dihydro-3H-pyrazol-3-one
  参考文献：
  名称：

  NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS

  摘要：

  化合物式(I)的化合物是一种新颖有效的第4型磷酸二酯酶抑制剂。

  公开号：

  US20110218201A1
• 作为产物：
  描述：

  5-Cyano-6-benzoyl-5,6-dihydro-1,6-naphthyridin 、 盐酸 生成 [1,6]萘啶-5-甲酸
  参考文献：
  名称：

  HAMADA YOSHIKI; SHIGEMURA KENTARO, YAKUGAKU DZASSI, YAKUGAKU ZASSNI, J. PHARM. SOS. JAR., 1979, 99, NO 12, 1+

  摘要：

  DOI：

文献信息

• Monoacylglycerol Lipase Modulators
  申请人：Janssen Pharmaceutica NV

  公开号：US20200102303A1

  公开（公告）日：2020-04-02

  Fused compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. Wherein R 1 , R 2 , R 2a , R 3 , R 3a , R 4 , and R 4a are defined herein.

  化合物的结构式（I）和结构式（II），含有它们的药物组合物，制备它们的方法，以及使用它们的方法，包括用于治疗与MGL调节相关的疾病状态、紊乱和病况的方法，例如与疼痛、精神障碍、神经障碍（包括但不限于重性抑郁障碍、治疗抵抗性抑郁症、焦虑性抑郁症、躁郁症）、癌症和眼部疾病相关的方法。 其中R1、R2、R2a、R3、R3a、R4和R4a在此处定义。
• 10a-Azalide Compound
  申请人：Sugimoto Tomohiro

  公开号：US20090281292A1

  公开（公告）日：2009-11-12

  [Object]: To provide a compound having a novel structure effective against Hemophilus influenzae and erythromycin resistant bacteria (for example, resistant pneumococci and streptococci) as well as against conventional erythromycin sensitive bacteria. [Solution]: A novel 10a-azalide compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof, or an intermediate for the preparation of the same. The compound of the present invention has superior antibacterial activity against Hemophilus influenzae , erythromycin resistant pneumococci and the like, and therefore, the compound can be used as a therapeutic agent of infectious diseases.

  【目标】提供一种具有新结构的化合物，对流感嗜血杆菌和红霉素耐药菌（例如耐药肺炎球菌和链球菌）以及传统的红霉素敏感菌具有有效作用。 【解决方案】本发明提供了一种新型10a-氮杂环十六元化合物，其化学式为（I），其药学上可接受的盐或其溶剂化物，或其制备的中间体。该化合物对流感嗜血杆菌、红霉素耐药性肺炎球菌等具有卓越的抗菌活性，因此可以作为治疗传染病的药物。
• NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS
  申请人：Schlemminger Imre

  公开号：US20110218201A1

  公开（公告）日：2011-09-08

  The compounds of Formula (I), are novel effective inhibitors of the type 4 phosphodiesterase.

  化合物式(I)的化合物是一种新颖有效的第4型磷酸二酯酶抑制剂。
• ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS
  申请人：Yamagishi Tatsuya

  公开号：US20120232052A1

  公开（公告）日：2012-09-13

  The present invention relates to aryl carboxamide derivatives of formula (I), wherein Ar 1 is phenyl; Ar 2 is aryl; n is 1-4; X is —O—, —S—, —SO— or —SO 2 —, a prodrug thereof or a pharmaceutically acceptable salt thereof, which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of such disorders and diseases as pain in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases as pain in which voltage gated sodium channels are involved.

  本发明涉及公式（I）的芳基羧酰胺衍生物，其中Ar1是苯基；Ar2是芳基；n为1-4；X为—O—、—S—、—SO—或—SO2—，其前体药物或其药学上可接受的盐，具有阻断电压门控钠通道如TTX-S通道的活性，并在治疗或预防涉及电压门控钠通道的疾病和疾病，如疼痛方面中有用。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的疾病和疾病，如疼痛方面的使用。
• Novel 3-Bicyclocarbonylaminopyridine-2-Carboxamides or 3-Bicyclocarbonylaminopyrazine-2-Carboxamides
  申请人：Amin Kosrat

  公开号：US20090181968A1

  公开（公告）日：2009-07-16

  The present invention relates to compounds of formula (I) [Chemical formula should be inserted here. Please see paper copy] as well as pharmaceutically acceptable salts and pharmaceutical compositions including the compounds are prepared or thereof: wherein, A 1 , A 2 , R 1 , R 2 , R 3 , R 4 , and R 5 and n are as defined in the specification. The compounds of formula (I) are useful in therapy.

  本发明涉及公式（I）的化合物[化学式应在此处插入。请参阅纸质副本]以及制备该化合物的药学上可接受的盐和制药组合物：其中，A1、A2、R1、R2、R3、R4、R5和n如规范所定义。公式（I）的化合物在治疗中有用。