(S)-2-amino-3-pyridin-3-ylpropanol | 167298-61-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (S)-2-amino-3-pyridin-3-ylpropanol
• 英文别名: (2S)-2-amino-3-(pyridin-3-yl)propan-1-ol；(I(2)S)-I(2)-Amino-3-pyridinepropanol；(2S)-2-amino-3-pyridin-3-ylpropan-1-ol
• CAS: 167298-61-5
• 化学式: C₈H₁₂N₂O
• 分子量: 152.196
• InChiKey: XKBHUHOUKQVIHT-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  59.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-chloro-5-cyclopropyl-2-((3,5-dimethoxyphenyl)amino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile 、 (S)-2-amino-3-pyridin-3-ylpropanol 在 三乙胺 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 24.0h， 以37%的产率得到5-cyclopropyl-2-(3,5-dimethoxyphenylamino)-7-((S)-1-hydroxymethyl-2-pyridin-3-ylethylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
  参考文献：
  名称：

  Novel pyrazolo[1,5-a]pyrimidines as c-Src kinase inhibitors that reduce IKr channel blockade

  摘要：

  To improve the in vitro potency of the c-Src inhibitor 1a and to address its hERG liability, a structure-activity study was carried Out, focusing on two regions of the lead compound. The blockade of the delayed cardiac current rectifier K+ (I-Kr) channel was overcome by replacing the ethylenediamino group with an amino alcohol group at the 7-position. In addition, modifying the substituents at the 5-position and the side chain groups on the amino alcohols at the 7-position enhanced the intracellular c-Src inhibitory activity and increased central nervous system (CNS) penetration. In the present study, 6l exhibited significant in vivo efficacy in a middle cerebral artery (MCA) occlusion model in rats. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.068

文献信息

• ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS
  申请人：Incyte Corporation

  公开号：US20130096144A1

  公开（公告）日：2013-04-18

  The present invention provides isoindolinone and pyrrolopyridinone derivatives, as well as their compositions and methods of use, that inhibit the activity of the serine/threonine kinase, Akt, and are useful in the treatment of diseases related to the activity of Akt including, for example, cancer and other diseases.

  本发明提供了异吲哚酮和吡咯吡啶酮衍生物，以及它们的组合物和使用方法，这些衍生物抑制丝氨酸/苏氨酸激酶Akt的活性，对于治疗与Akt活性相关的疾病，例如癌症和其他疾病，具有益处。
• [EN] 2,6-DIAMINOPURINE DERIVATIVES<br/>[FR] DERIVES DE LA 2,6-DIAMINOPURINE
  申请人：GLAXO GROUP LIMITED

  公开号：WO1994017090A1

  公开（公告）日：1994-08-04

  (EN) 2,6-Diaminopurine-$g(b)-D-ribofuranuronamide derivatives are described having general formula (I) and salts and solvates thereof, wherein: R1 is hydrogen, C3-8cycloalkyl or C1-6alkyl; R2 is C3-8cycloalkyl, C3-8cycloalkylC1-6alkyl, Alk1Y, -(CHR5)m(Alk2)nZ or appropriately substituted C3-8cycloalkyl, C3-8cycloalkylC1-6alkyl, pyrrolidin-3-yl, 2-oxopyrrolidin-4-yl, 2-oxopyrrolidin-5-yl, piperidin-3-yl or piperidin-4-yl, and Q is oxygen or sulphur. Compounds of formula (I) and their salts and solvates have use in medicine as anti-inflammatory agents, particularly in the treatment of patients with inflammatory conditions who are susceptible to leukocyte-induced tissue damage.(FR) On décrit des dérivés du 2,6-diaminopurine-$g(b)-D-ribofuranuronamide ayant la formule générale (I) ainsi que leurs sels et solvates. Dans cette formule: R1 est un hydrogène, un C3-8cycloalkyle ou un C1-6alkyle; R2 est un C3-8cycloalkyle, un C3-8cycloalkylC1-6alkyle, un Alk1Y, un -(CHR5)m(Alk2)nZ ou un des groupes suivants, portant des substituants appropriés: C3-8cycloalkyle, C3-8cycloalkylC1-6alkyle, pyrrolidin-3-yle, 2-oxopyrrolidin-4-yle, 2-oxopyrrolidin-5-yle, pipéridin-3-yle ou pipéridin-4-yle, et Q est oxygène ou le soufre. Les composés de la formule (I) et leurs sels et solvates sont utiles en médecine comme agents anti-inflammatoires, en particulier pour le traitement de patients souffrant d'affections inflammatoires avec risques de lésions tissulaires, induites par les leucocytes.

  描述了具有通式(I)及其盐和溶剂化物的2,6-二氨基嘌呤-$g(b)-D-核糖尿苷衍生物，其中：R1为氢、C3-8环烷基或C1-6烷基；R2为C3-8环烷基、C3-8环烷基C1-6烷基、Alk1Y、-(CHR5)m(Alk2)nZ或适当取代的C3-8环烷基、C3-8环烷基C1-6烷基、吡咯烷-3-基、2-氧代吡咯烷-4-基、2-氧代吡咯烷-5-基、哌啶-3-基或哌啶-4-基，Q为氧或硫。通式(I)化合物及其盐和溶剂化物在医学上具有抗炎作用，特别是用于治疗易受白细胞诱导的组织损伤的炎症病患。
• 2,6-DIAMINOPURINE DERIVATIVES
  申请人：GLAXO GROUP LIMITED

  公开号：EP0680488A1

  公开（公告）日：1995-11-08
• US5889178A
  申请人：——

  公开号：US5889178A

  公开（公告）日：1999-03-30
• US5925624A
  申请人：——

  公开号：US5925624A

  公开（公告）日：1999-07-20