anti-3-(O-Carboxymethyl)oxyiminoprogesteron | 58116-42-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: anti-3-(O-Carboxymethyl)oxyiminoprogesteron
• 英文别名: Progesterone 3-carboxymethyloxime；2-[(E)-[(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]amino]oxyacetic acid
• CAS: 58116-42-0
• 化学式: C₂₃H₃₃NO₄
• 分子量: 387.519
• InChiKey: PPELYUTTZHLIAZ-CDUDAXDSSA-N

物化性质

• 沸点：
  537.5±60.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  76
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  五氟苯酚 、 anti-3-(O-Carboxymethyl)oxyiminoprogesteron 在 polymer supported ethyl dimethylaminopropylcarbodiimide 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 14.0h， 以78%的产率得到[(8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-(3E)-ylideneaminooxy]-acetic acid pentafluorophenyl ester
  参考文献：
  名称：

  通过固体支持的EDAC轻松制备半抗原活性酯

  摘要：

  生物缀合物优选地通过使感兴趣的半抗原的活性酯与蛋白质反应来制备。用固体负载的EDAC和N-羟基琥珀酰亚胺或五氟苯酚制备活性酯可提供具有优异收率和纯度的活性酯

  DOI：

  10.1016/0040-4039(95)01761-6
• 作为产物：
  描述：

  Progesteron-3-(O-carboxymethyl)-oxim-methylester 在 sodium phosphate 、 Triton X-100 作用下， 反应 48.0h， 生成 syn-3-(O-Carboxymethyl)oxyiminoprogesteron 、 anti-3-(O-Carboxymethyl)oxyiminoprogesteron
  参考文献：
  名称：

  Lipase mediated diastereoselective hydrolysis of steroidal 3-(O-carboxymethyl) oxime methyl esters

  摘要：

  A series of geometric isomeric mixtures of steroidal 3-(O-carboxymethyl) oxime methyl esters 1-4 were hydrolyzed with high diastereoselectivity for the anti isomer with crude lipase from Candida cylindracea.

  DOI：

  10.1016/s0957-4166(00)80344-4

文献信息

• Industrial process for food liquids decontamination from chemical and/or biological contaminants
  申请人：Volpato Ivo

  公开号：US20050220936A1

  公开（公告）日：2005-10-06

  Procedure for the decontamination of a food liquid from one or more chemical and/or biological contaminants, based on the contact of said liquid with at least a biocompatible membrane, to which antibodies specific for said contaminants are covalently bound.

  一种用于将食品液体从一种或多种化学和/或生物污染物中脱除的程序，基于该液体与至少一个生物相容性膜的接触，该膜上共价结合了特异于所述污染物的抗体。
• Methods and compositions for control of disease in aquaculture
  申请人：Durvasula Ravi

  公开号：US20080107652A1

  公开（公告）日：2008-05-08

  The invention discloses paratransgenesis methods for prevention, amelioration or treatment of a disease or disorder in an aquatic animal. The method comprises providing a genetically modified micro algae that expresses a recombinant molecule that specifically targets one or more key epitopes of a pathogen that infects the aquatic animal and ii) feeding the aquatic animal directly or indirectly with the genetically modified unicellular algae.

  本发明公开了一种利用副转基因方法预防、改善或治疗水生动物疾病或疾患的方法。该方法包括提供一种基因改造的微型藻类，该微型藻类表达一种重组分子，该分子特异性靶向感染水生动物的病原体的一个或多个关键表位，以及直接或间接地将基因改造的单细胞藻类喂养给水生动物。
• Methods and Compositions for control of disease in aquaculture
  申请人：Durvasula Ravi

  公开号：US20110158946A1

  公开（公告）日：2011-06-30

  The invention discloses paratransgenesis methods for prevention, amelioration and/or treatment of a disease or disorder in an aquatic animal. The method comprises providing a genetically modified micro algae that expresses a recombinant molecule that specifically targets one or more key epitopes of a pathogen that infects the aquatic animal and ii) feeding the aquatic animal directly or indirectly with the genetically modified unicellular algae.

  本发明公开了一种用于预防、改善和/或治疗水生动物疾病或障碍的副转基因方法。该方法包括提供一种基因修饰的微藻，该微藻表达一种重组分子，该分子特异性靶向感染水生动物的病原体的一个或多个关键表位，并且(ii) 直接或间接地将基因修饰的单细胞藻类喂给水生动物。
• Immunoassay methods and reagents and methods for producing the latter
  申请人：CYBERFLUOR INC.

  公开号：EP0290269A2

  公开（公告）日：1988-11-09

  Immunoassay and methods for using fluorescent chelates of lanthanide metal ions in conjunction with immunoreactive bodies to permit fluorescent assay in liquid or dry samples. The assay reagent comprises a residue of an immunoreactive body linked to a residue of a protein or polypeptide. The protein or polypeptide is labelled by substitution with a ligand forming a fluorescent chelate with lanthanide metal ion such as europium. The reagent when used in an immunoassay, binds to the immobilized immunoreactive body and excess is washed away. The sample can be dried for later analysis by a suitable fluoremeter.

  将镧系金属离子的荧光螯合物与免疫活性体结合使用以允许在液体或干燥样品中进行荧光测定的免疫测定和方法。 检测试剂包括与蛋白质或多肽残基相连的免疫活性体残基。 蛋白质或多肽通过与镧系金属离子（如铕）形成荧光螯合物的配体取代而被标记。 用于免疫测定时，试剂与固定的免疫反应体结合，多余的试剂被洗去。 样品可以烘干，以便以后用合适的荧光测定仪进行分析。
• Reagent for immunoassay, and kit containing the same
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP0383313A2

  公开（公告）日：1990-08-22

  A reagent for use in an immunoassay for measuring haptens, antigens or antibodies by means of a competitive binding method, which comprises a combination of an antibody and a labelled hapten or a labelled antigen or a combination of a hapten or an antigen and a labelled antibody, wherein the antibody and the labelled hapten or the labelled antigen in one combination or the hapten or the antigen and the labelled antibody in another combination are capable of undergoing reversible binding, and a device for use in an immunoassay wherein the reagent of the present invention is included in a single container. An immunoassay can be performed in a short time by the use of the immunoassay device of the present invention.

  一种用于免疫测定的试剂，通过竞争结合的方法来测量杂合体、抗原或抗体，该试剂 包括抗体与标记的杂合体或标记的抗原的组合，或杂合体或抗原与标记的抗体的组合、其中一种组合中的抗体和标记的合蛋白或标记的抗原，或另一种组合中的合蛋白或抗原和标记的抗体能够进行可逆结合，以及一种用于免疫测定的装置，其中本发明的试剂包含在一个容器中。 使用本发明的免疫测定装置可在短时间内完成免疫测定。