2-methyl-tetrahydropyran-3-one | 30448-27-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-methyl-tetrahydropyran-3-one
• 英文别名: 2-methyldihydro-2H-pyran-3(4H)-one；2-Methyloxan-3-one
• CAS: 30448-27-2
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: LFJBBDLJNBHRBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methyl-tetrahydropyran-3-one 生成 1,2,3,6-tetradeoxy-4-D-erythro-hexopyranose
  参考文献：
  名称：

  CATELANI G.; MONTI L.; UGAZIO M., J. ORG. CHEM., 1980, 45, NO 5, 919-920

  摘要：

  DOI：

文献信息

• Aldol additions of pinacolone lithium enolate with ketones: reactivities governed predominantly by field effects
  作者：Goutam Das、Edward R. Thornton

  DOI：10.1021/ja00057a012

  日期：1993.2

  The relative reactivities of representative α- and β-heterosubstituted acyclic, cyclic (five- and six-membered), and aromatic ketones with the lithium enolate of pinacolone in diethyl ether at -78 o C were determined. The order of reactivitiesof monosubstituted acetones (MeCOCH 2 X) is X=Cl>OTBDMS>OMe>SMe>NMe 2 >CH 2 SM>H>Me and spans a range of 10 4

  测定了代表性的 α- 和 β- 杂取代的无环、环状（五元和六元）和芳香酮与频哪酮的烯醇锂在 -78 o C 的二乙醚中的相对反应性。单取代丙酮 (MeCOCH 2 X) 的反应性顺序为 X=Cl>OTBDMS>OMe>SMe>NMe 2 >CH 2 SM>H>Me，范围为 10 4
• ALDOSTERONE SYNTHASE INHIBITORS
  申请人：BALESTRA Michael

  公开号：US20140323468A1

  公开（公告）日：2014-10-30

  The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 . R 3 , R 4 , R 5 , R 6 , R 7 , W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

  本发明涉及以下式（I）的化合物及其药学上可接受的盐，其中R1、R2、R3、R4、R5、R6、R7、W、Y、m和n如本文所定义。该发明还涉及包括这些化合物的药物组合物，使用这些化合物治疗各种疾病和紊乱的方法，制备这些化合物的方法以及在这些过程中有用的中间体。
• [EN] AMIDOPYRIMIDONE DERIVATIVES<br/>[FR] DÉRIVÉS D'AMIDOPYRIMIDONE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2021259815A1

  公开（公告）日：2021-12-30

  The present invention provides compounds of formula I or II: wherein X1, X3, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

  本发明提供了以下公式I或II的化合物：其中X1、X3、R1、R2、R3、R4和R5如本文所述，以及其药学上可接受的盐。此外，本发明涉及制备公式I的化合物、包含它们的药物组合物以及它们作为药物的用途。
• Method for the production of a mixture of lactide derivatives
  申请人：Hagen Rainer

  公开号：US20120149920A1

  公开（公告）日：2012-06-14

  A mixture of cyclic diesters derived from lactic acid and in cases a mixture of a racemate of dilactide may be produced in several different processes. In some instances, the process can thereby start from the corresponding alpha-hydroxycarboxylic acids, the corresponding cyclic diesters or oligomers of the corresponding alpha-hydroxycarboxylic acids.

  一种由乳酸衍生的环状二酯混合物，有时也包括二乳酸酯的混合物，可以通过几种不同的过程生产。在某些情况下，该过程可以从相应的α-羟基羧酸、相应的环状二酯或相应的α-羟基羧酸低聚物开始。
• PRODUCTION METHOD FOR 1, 4-BUTANEDIOL
  申请人：Mitsubishi Chemical Corporation

  公开号：EP2857377A1

  公开（公告）日：2015-04-08

  An object of the present invention is to provide high-quality 1,4BG capable of working out to a raw material of PBT with good color tone, by efficiently removing and refining impurities mixed when producing a biomass-derived 1,4BG on an industrial scale. The present invention relates to a production method of refined 1,4BG, where a crude 1,4BG-containing solution is obtained from refined raw material 1,4BG obtained by removing bacterial cells, salt contents and water from the fermentation culture medium, through a step of removing high-boiling-point components and/or low-boiling-point components by distillation and/or a step of converting an unsaturated compound to a hydride and the target product is obtained as a side stream in a further distillation step.

  本发明的目的是通过有效地去除和精制工业化生产生物质衍生 1,4BG 时混入的杂质，提 供能够加工成色调良好的 PBT 原料的高质量 1,4BG。本发明涉及一种精制 1,4BG的生产方法，其中通过蒸馏去除高沸点成分和/或低沸点成分的步骤和/或将不饱和化合物转化为氢化物的步骤，从精制原料 1,4BG 中去除细菌细胞、盐含量和发酵培养基中的水分，得到含 1,4BG 的粗溶液，并在进一步的蒸馏步骤中作为侧流得到目标产品。