4-(3-Hydroxy-butoxy)-2,3-diphenyl-cyclopenta-2,4-dienone | 187223-49-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-(3-Hydroxy-butoxy)-2,3-diphenyl-cyclopenta-2,4-dienone
• 英文别名: 4-(3-Hydroxybutoxy)-2,3-diphenylcyclopenta-2,4-dien-1-one
• CAS: 187223-49-0
• 化学式: C₂₁H₂₀O₃
• 分子量: 320.388
• InChiKey: UXBQYOGQEQGJII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(3-Hydroxy-butoxy)-2,3-diphenyl-cyclopenta-2,4-dienone 在 oxonium 、 对甲苯磺酸 作用下， 生成 4-Cyclopentene-1,3-dione, 4,5-diphenyl-
  参考文献：
  名称：

  Effect of solvent polarity extremes on the coupling of cyclopropylcarbene-chromium complexes and alkynes: Synthesis of β-alkoxycyclopentadienones, 2-cyclopentene-1,3-diones, and cis 4,5-disubstituted cyclopentenones

  摘要：

  The reaction between acetylenes and cyclopropylcarbene-chromium complexes in hexane affords exclusively cyclopentadienone derivatives in good yield, which are readily hydrolyzed to cyclopentenediones. The analogous reaction in 50:50 water dioxane affords cis disubstituted cyclopentenones. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0040-4039(96)02282-4
• 作为产物：
  描述：

  二苯基乙炔 、 alkaline earth salt of/the/ methylsulfuric acid 以 正己烷 为溶剂， 反应 3.0h， 以59%的产率得到4-(3-Hydroxy-butoxy)-2,3-diphenyl-cyclopenta-2,4-dienone
  参考文献：
  名称：

  Effect of solvent polarity extremes on the coupling of cyclopropylcarbene-chromium complexes and alkynes: Synthesis of β-alkoxycyclopentadienones, 2-cyclopentene-1,3-diones, and cis 4,5-disubstituted cyclopentenones

  摘要：

  The reaction between acetylenes and cyclopropylcarbene-chromium complexes in hexane affords exclusively cyclopentadienone derivatives in good yield, which are readily hydrolyzed to cyclopentenediones. The analogous reaction in 50:50 water dioxane affords cis disubstituted cyclopentenones. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0040-4039(96)02282-4

文献信息

• Effect of solvent polarity extremes on the coupling of cyclopropylcarbene-chromium complexes and alkynes: Synthesis of β-alkoxycyclopentadienones, 2-cyclopentene-1,3-diones, and cis 4,5-disubstituted cyclopentenones
  作者：James W. Herndon、Paren P. Patel

  DOI：10.1016/s0040-4039(96)02282-4

  日期：1997.1

  The reaction between acetylenes and cyclopropylcarbene-chromium complexes in hexane affords exclusively cyclopentadienone derivatives in good yield, which are readily hydrolyzed to cyclopentenediones. The analogous reaction in 50:50 water dioxane affords cis disubstituted cyclopentenones. Copyright (C) 1996 Elsevier Science Ltd