1-(2-methylprop-1-enyl)-2-naphthol | 25711-86-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(2-methylprop-1-enyl)-2-naphthol
• 英文别名: 1-(2-methylprop-1-en-1-yl)-2-naphthol；(2,2-Dimethylvinyl)-2-naphthol；1-(2-Methylprop-1-enyl)naphthalen-2-ol
• CAS: 25711-86-8
• 化学式: C₁₄H₁₄O
• 分子量: 198.265
• InChiKey: WMHLILVLCPFQOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(2-methylprop-1-enyl)-2-naphthol 、 丙烯胺 以 乙腈 为溶剂， 反应 6.0h， 以43%的产率得到1-(1-allylamino-2-methylpropyl)-2-naphthol
  参考文献：
  名称：

  Yasuda, Masahide; Sone, Tatsuya; Tanabe, Kimiko, Journal of the Chemical Society. Perkin transactions I, 1995, # 4, p. 459 - 464

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(1-Hydroxy-2-methyl-propyl)-naphthalen-2-ol 生成 1-(2-methylprop-1-enyl)-2-naphthol
  参考文献：
  名称：

  Yasuda, Masahide; Sone, Tatsuya; Tanabe, Kimiko, Journal of the Chemical Society. Perkin transactions I, 1995, # 4, p. 459 - 464

  摘要：

  DOI：

文献信息

• Alkenylation of 1- and 2-Naphthols by Using Magnesium Alkylidene Carbenoids as Electrophilic Alkenylating Agents
  作者：Tsuyoshi Satoh、Tsutomu Kimura、Masaya Watanabe、Gaku Kashiwamura、Jo Sakurada

  DOI：10.1055/s-0032-1318132

  日期：——

  1- and 2-Naphthols were successfully alkenylated in a regioselective manner by treating the corresponding lithium 1- and 2-naphtholates with magnesium alkylidene carbenoids. The magnesium alkylidene carbenoids were generated in situ by a sulfoxide-magnesium exchange reaction of 1-chlorovinyl 4-tolyl sulfoxides with isopropylmagnesium chloride. The reaction of magnesium alkylidene carbenoids with lithium 2-naphtholates took place at the 1-position of the naphthyl ring to give 1-(alk-1-enyl)-2-naphthols in respectable yields. The alkenylation of 1-naphthols proceeded at the 2-position of the naphthol ring to give 2-(alk-1-enyl)-1-naphthols in yields of 56-67%. In contrast to the reaction of lithium naphtholates with magnesium alkylidene carbenoids, the reaction of lithium phenolates gave low yields of the corresponding alk-1-enyl aryl ethers.
• Anti-Bacterial Compounds
  申请人：Parker Jane Katy

  公开号：US20080096894A1

  公开（公告）日：2008-04-24

  Compounds of formula (I), or salts or solvates thereof, in vitro as inhibitors of growth of Gram-positive bacteria, where A is selected from formula (a).
• US7514406B2
  申请人：——

  公开号：US7514406B2

  公开（公告）日：2009-04-07
• Yasuda, Masahide; Sone, Tatsuya; Tanabe, Kimiko, Journal of the Chemical Society. Perkin transactions I, 1995, # 4, p. 459 - 464
  作者：Yasuda, Masahide、Sone, Tatsuya、Tanabe, Kimiko、Shima, Kensuke

  DOI：——

  日期：——