19-去甲羊毛甾-5,24-二烯-3-醇,9-甲基-,(3b,8a,9b,10a,13a,14b,17a)- | 129443-33-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 19-去甲羊毛甾-5,24-二烯-3-醇,9-甲基-,(3b,8a,9b,10a,13a,14b,17a)-
• 英文名称: antiquol B
• 英文别名: (3S,8S,9R,10S,13S,14R,17S)-4,4,9,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 129443-33-0
• 化学式: C₃₀H₅₀O
• 分子量: 426.726
• InChiKey: WSPRAEIJBDUDRX-BAZAUMFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 19-去甲羊毛甾-5,24-二烯-3-醇,9-甲基-,(3b,8a,9b,10a,13a,14b,17a)- 在 吡啶 作用下， 生成 antiquol B acetate
  参考文献：
  名称：

  Eupha-7,9(11),24-trien-3β-ol (“Antiquol C”) and Other Triterpenes from Euphorbia antiquorum Latex and Their Inhibitory Effects on Epstein−Barr Virus Activation

  摘要：

  The structures of three triterpene alcohols isolated from the latex of Euphorbia antiquorum were established to be eupha-7,9(11),24-trien-3beta-ol (2; antiquol C), 19(10-->9)abeo-8alpha,9,10alpha-eupha-5,24-dien-3beta-ol (3; antiquol B), and 24-methyltirucalla-8,24(24(1))-dien-3beta-ol (4; euphorbol) on the basis of spectroscopic methods. Compounds 3 and 4 have previously been assigned the erroneous structures of 10alpha-cucurbita-5,24-dien-3alpha-ol and 24-methyleupha-8,24(24(1))-dien-3beta-ol, respectively. Compounds 2-4 and four other known compounds isolated from the latex, euphol (1), lemmaphylla-7,21-dien-3beta-ol (5), isohelianol (6), and camelliol C (7), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).

  DOI：

  10.1021/np010377y

文献信息

• Eupha-7,9(11),24-trien-3β-ol (“Antiquol C”) and Other Triterpenes from <i>Euphorbia </i><i>a</i><i>ntiquorum</i> Latex and Their Inhibitory Effects on Epstein−Barr Virus Activation
  作者：Toshihiro Akihisa、E. M. Kithsiri Wijeratne、Harukuni Tokuda、Fumio Enjo、Masakazu Toriumi、Yumiko Kimura、Kazuo Koike、Tamotsu Nikaido、Yasuhiro Tezuka、Hoyoku Nishino

  DOI：10.1021/np010377y

  日期：2002.2.1

  The structures of three triterpene alcohols isolated from the latex of Euphorbia antiquorum were established to be eupha-7,9(11),24-trien-3beta-ol (2; antiquol C), 19(10-->9)abeo-8alpha,9,10alpha-eupha-5,24-dien-3beta-ol (3; antiquol B), and 24-methyltirucalla-8,24(24(1))-dien-3beta-ol (4; euphorbol) on the basis of spectroscopic methods. Compounds 3 and 4 have previously been assigned the erroneous structures of 10alpha-cucurbita-5,24-dien-3alpha-ol and 24-methyleupha-8,24(24(1))-dien-3beta-ol, respectively. Compounds 2-4 and four other known compounds isolated from the latex, euphol (1), lemmaphylla-7,21-dien-3beta-ol (5), isohelianol (6), and camelliol C (7), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).