giganteone A

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: giganteone A
• 英文别名: 9-(3,4-dihydroxyphenyl)-1-[3-[2-[9-(2,6-dihydroxyphenyl)-9-oxononyl]-4,5-dihydroxyphenyl]-2,6-dihydroxyphenyl]nonan-1-one
• 化学式: C₄₂H₅₀O₁₀
• 分子量: 714.853
• InChiKey: YLOQHHSJSFTBRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.1
• 重原子数：
  52
• 可旋转键数：
  21
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  196
• 氢给体数：
  8
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  马拉巴酮C 在 rhus laccase 作用下， 以 甲醇 、 水 为溶剂， 反应 72.0h， 以25%的产率得到giganteone A
  参考文献：
  名称：

  Novel cytotoxic acylphenol dimers of Myristica gigantea; enzymatic synthesis of giganteones A and B

  摘要：

  Three new compounds, prepromalabaricone B (1) and two dimeric acylphenols, giganteones A (2) and B (3) were isolated from EtOAc extract of the fruits of Myristica gigantea (Myristicaceae), together with known promalabaricone C (4), malabaricones A-C (5-7) and maingayone (8). The structures were determined by mass and 2D NMR spectral analysis, and the enzymatic synthesis of giganteones A and B was performed from malabaricone C. Both 2 and 3 possess significant cytotoxic activity in vitro against human nasopharynx KB cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00537-9

文献信息

• Novel cytotoxic acylphenol dimers of Myristica gigantea; enzymatic synthesis of giganteones A and B
  作者：Van Cuong Pham、Akino Jossang、Thierry Sévenet、Bernard Bodo

  DOI：10.1016/s0040-4020(02)00537-9

  日期：2002.7

  Three new compounds, prepromalabaricone B (1) and two dimeric acylphenols, giganteones A (2) and B (3) were isolated from EtOAc extract of the fruits of Myristica gigantea (Myristicaceae), together with known promalabaricone C (4), malabaricones A-C (5-7) and maingayone (8). The structures were determined by mass and 2D NMR spectral analysis, and the enzymatic synthesis of giganteones A and B was performed from malabaricone C. Both 2 and 3 possess significant cytotoxic activity in vitro against human nasopharynx KB cells. (C) 2002 Elsevier Science Ltd. All rights reserved.