2-[6'-(Azidomethoxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl]oxyacetic acid | 1132832-90-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-[6'-(Azidomethoxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl]oxyacetic acid
• CAS: 1132832-90-6
• 化学式: C₂₃H₁₅N₃O₇
• 分子量: 445.388
• InChiKey: RLVIYFIUPBVWTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-羟基丁二酰亚胺 、 2-[6'-(Azidomethoxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl]oxyacetic acid 在 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成 (2,5-Dioxopyrrolidin-1-yl) 2-[6'-(azidomethoxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl]oxyacetate
  参考文献：
  名称：

  FLUORESCENT MOLECULE FROM A PROFLUOROPHORE

  摘要：

  公开号：

  EP2204371B1
• 作为产物：
  描述：

  Methyl 2-[6'-(azidomethoxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl]oxyacetate 在 水 、 sodium hydroxide 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 生成 2-[6'-(Azidomethoxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl]oxyacetic acid
  参考文献：
  名称：

  FLUORESCENT MOLECULE FROM A PROFLUOROPHORE

  摘要：

  公开号：

  EP2204371B1

文献信息

• FLUORESCENT MOLECULE
  申请人：Abe Hiroshi

  公开号：US20110076680A1

  公开（公告）日：2011-03-31

  It is an object of the present invention to provide an on-off type fluorescent compound (a fluorescence-producing molecule system) used in gene analyses, which is highly stable (namely, being active for a long period of time) and highly sensitive, and which enables amplification of a trace amount of gene signal and observation thereof. The present invention provides a nonfluorescent molecule having a fluorescent substance skeleton such as fluorescein skeleton and having a group represented by —O—C(Y1)(Y2)-N 3 wherein each of Y1 and Y2 represents a hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, an alkoxy group containing 1 to 6 carbon atoms, an aryl group containing 6 to 10 carbon atoms, or a cyano group, in the molecule.
• Oligonucleotide-Templated Photoreduction Fluorogenic Probe Pairs and Their Use in Quantitative Detection of Target RNA Sequences
  申请人：Jan Biotech, Inc.

  公开号：US20220127670A1

  公开（公告）日：2022-04-28

  This application describes a fluorogenic nucleic acid kit or composition for quantitative detection of a target ribonucleic acid (RNA) sequence in a test sample comprising at least one pair of oligonucleotide probes comprising a photocatalyst probe and a profluorophore probe, wherein one of the photocatalyst probe and the profluorophore probe is complementary to and capable of specifically binding an upstream portion of the target RNA sequence, and the other probe is complementary to and capable of specifically binding to a downstream portion of the target RNA sequence, the photocatalyst probe comprises a first oligonucleotide covalently bound to a photocatalyst, the profluorophore probe comprises a second oligonucleotide covalently bound to a profluorophore, and the photocatalyst is activatable by exposure to light and a reducing agent to form a reduced, activated photocatalyst that, when both probes of the pair are hybridized to the target RNA sequence, is capable of photoreducing the profluorophore to form a detectable fluorophore. The application also describes methods for quantitative detection of target RNA.
• US8084201B2
  申请人：——

  公开号：US8084201B2

  公开（公告）日：2011-12-27
• FLUORESCENT MOLECULE FROM A PROFLUOROPHORE
  申请人：Riken

  公开号：EP2204371B1

  公开（公告）日：2012-12-12