4-chloro-1-(2-chloro-2-phenylethyl)-N,N-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine | 1104075-96-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 4-chloro-1-(2-chloro-2-phenylethyl)-N,N-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine
• 英文别名: 4-chloro-1-(2-chloro-2-phenylethyl)-N,N-dimethylpyrazolo[3,4-d]pyrimidin-6-amine
• CAS: 1104075-96-8
• 化学式: C₁₅H₁₅Cl₂N₅
• 分子量: 336.224
• InChiKey: NDMAQWVOFLXLOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  吗啉 、 4-chloro-1-(2-chloro-2-phenylethyl)-N,N-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine 以 甲苯 为溶剂， 以79%的产率得到1-(2-chloro-2-phenylethyl)-N,N-dimethyl-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-amine
  参考文献：
  名称：

  Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines

  摘要：

  The synthesis of new 4-amino substituted pyrazolo[3,4-d]pyrimidines along with their activity in cell-free enzymatic assays on Src and Abl tyrosine kinases is reported. Some compounds emerged as good dual inhibitors of the two enzymes, showed antiproliferative effects on two Bcr-Abl positive leukemia cell lines K-562 and KU-812, and induced apoptosis, as demonstrated by the PARP assay. Docking studies have been also performed to analyze the binding mode of compounds under study and to identify the structural determinants of their interaction with both Src and Abl. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.01.034
• 作为产物：
  描述：

  N'-[4-cyano-1-(2-hydroxy-2-phenylethyl)-1H-pyrazol-5-yl]-N,N-dimethylcarbamimidic chloride 在 盐酸 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 48.0h， 以65%的产率得到4-chloro-1-(2-chloro-2-phenylethyl)-N,N-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine
  参考文献：
  名称：

  Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines

  摘要：

  The synthesis of new 4-amino substituted pyrazolo[3,4-d]pyrimidines along with their activity in cell-free enzymatic assays on Src and Abl tyrosine kinases is reported. Some compounds emerged as good dual inhibitors of the two enzymes, showed antiproliferative effects on two Bcr-Abl positive leukemia cell lines K-562 and KU-812, and induced apoptosis, as demonstrated by the PARP assay. Docking studies have been also performed to analyze the binding mode of compounds under study and to identify the structural determinants of their interaction with both Src and Abl. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.01.034

文献信息

• Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines
  作者：Silvia Schenone、Chiara Brullo、Olga Bruno、Francesco Bondavalli、Luisa Mosti、Giovanni Maga、Emmanuele Crespan、Fabio Carraro、Fabrizio Manetti、Cristina Tintori、Maurizio Botta

  DOI：10.1016/j.ejmech.2008.01.034

  日期：2008.12

  The synthesis of new 4-amino substituted pyrazolo[3,4-d]pyrimidines along with their activity in cell-free enzymatic assays on Src and Abl tyrosine kinases is reported. Some compounds emerged as good dual inhibitors of the two enzymes, showed antiproliferative effects on two Bcr-Abl positive leukemia cell lines K-562 and KU-812, and induced apoptosis, as demonstrated by the PARP assay. Docking studies have been also performed to analyze the binding mode of compounds under study and to identify the structural determinants of their interaction with both Src and Abl. (C) 2008 Elsevier Masson SAS. All rights reserved.