N-Boc-2-bromoaminoethane | 1381947-86-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-Boc-2-bromoaminoethane
• 英文别名: tert-butyl N-bromo-N-ethylcarbamate
• CAS: 1381947-86-9
• 化学式: C₇H₁₄BrNO₂
• 分子量: 224.098
• InChiKey: GQCHIWCXZOBMCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  9-((tert-butyldimethylsilyl)oxy)-3-(2-(4-(6-hydroxybenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 、 N-Boc-2-bromoaminoethane 在 potassium carbonate 作用下， 以 氘代丙酮 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 tert-butyl (2-((3-(1-(2-(9-((tert-butyldimethylsilyl)oxy)-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl)ethyl)piperidin-4-yl)benzo[d]isoxazol-6-yl)oxy)ethyl)carbamate
  参考文献：
  名称：

  Antibodies to Risperidone Haptens and Use Thereof

  摘要：

  揭示了一种与利培酮结合的抗体，可用于在样本中检测利培酮，例如在竞争性免疫分析方法中。该抗体可用于侧向流动检测装置中，用于快速检测利培酮，包括在单个侧向流动检测装置中多重检测阿立哌唑、奥氮平、喹硫平和利培酮。

  公开号：

  US20140057301A1

文献信息

• [EN] 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG<br/>[FR] DÉRIVÉS DE 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE EN TANT QU'INHIBITEURS DE LA PARG
  申请人：CANCER REC TECH LTD

  公开号：WO2016092326A1

  公开（公告）日：2016-06-16

  The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

  本发明涉及作为PARG（Poly ADP-ribose glycohydrolase）酶活性抑制剂的I式化合物，其中R1a、R1b、R1c、R1d、R1e、W、X1、X2、X3、X4、X5、X6、X7、c如本文所定义。本发明还涉及制备这些化合物的方法，包括含有它们的药物组合物，以及它们在治疗增殖性疾病（如癌症）以及其他涉及PARG活性的疾病或症状中的用途。
• [EN] HAPTENS OF RISPERIDONE AND PALIPERIDONE<br/>[FR] HAPTÈNES DE RISPÉRIDONE ET DE PALIPÉRIDONE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014031601A1

  公开（公告）日：2014-02-27

  The invention relates to compounds of Formula (I), wherein R1 and R2 are defined in the specification, useful for the synthesis of novel conjugates and imrnunogens derived from risperidone and paliperidone. The invention also relates to conjugates of a risperidone or paliperidone hapten and a protein.

  本发明涉及式I化合物，其中R1和R2在说明书中定义，可用于合成源自利培酮和帕利哌酮的新型缀合物和免疫原。本发明还涉及利培酮或帕利哌酮半抗原与蛋白质的缀合物。
• [EN] PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS<br/>[FR] DERIVES DE PYRIDINE ET LEUR UTILISATION COMME ANTAGONISTES DE L'UROTENSINE II
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2005030209A1

  公开（公告）日：2005-04-07

  The invention relates to novel pyridine derivatives of formula 1 and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and their use as neurohormonal antagonists, especially as urotensin II inhibitors.

  该发明涉及公式1的新型吡啶衍生物和相关化合物，以及它们作为药物组成物中的活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组成物，以及它们作为神经荷尔蒙拮抗剂的用途，特别是作为尿泉素II抑制剂。
• HAPTENS OF RISPERIDONE AND PALIPERIDONE
  申请人：Ortho-Clinical Diagnostics, Inc.

  公开号：US20140155585A1

  公开（公告）日：2014-06-05

  The invention relates to compounds of Formula I, wherein R 1 and R 2 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from risperidone and paliperidone. The invention also relates to conjugates of a risperidone or paliperidone hapten and a protein.

  本发明涉及公式I的化合物，其中R1和R2在规范中定义，用于合成从利培酮和帕利哌酮衍生的新型结合物和免疫原。本发明还涉及利培酮或帕利哌酮半抗原和蛋白质的结合物。
• Haptens of risperidone and paliperidone
  申请人：Janssen Pharmaceutica NV

  公开号：US09012648B2

  公开（公告）日：2015-04-21

  The invention relates to compounds of Formula I, wherein R1 and R2 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from risperidone and paliperidone. The invention also relates to conjugates of a risperidone or paliperidone hapten and a protein.

  本发明涉及公式I的化合物，其中R1和R2在规范中定义，用于合成来源于利培酮和帕利哌酮的新型结合物和免疫原。本发明还涉及利培酮或帕利哌酮半抗原和蛋白质的结合物。