HPH-15 | 1009838-93-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: HPH-15
• 英文别名: 2-N,6-N-bis(2-tert-butylsulfanylethyl)pyridine-2,6-dicarbothioamide
• CAS: 1009838-93-0
• 化学式: C₁₉H₃₁N₃S₄
• 分子量: 429.739
• InChiKey: JFUQLHSMAKQEMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  152
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-N,6-N-bis(2-tert-butylsulfanylethyl)pyridine-2,6-dicarboxamide 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以98%的产率得到HPH-15
  参考文献：
  名称：

  Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure–activity relationships

  摘要：

  The compound named Histidine-pyridine-histidine (HPH) is an oxygen-activating ligand derived from the structure of bleomycin. We synthesized HPH derivatives, namely HPH-1 to -8, and investigated their antiviral activities against herpes simplex virus type 1. HPH-8 showed potent antiviral activity with an EC50 of 15 mu M, and relatively high cytotoxicity with a CC50 of 37 mu m In contrast, HPH-4 indicated a weaker antiviral activity with an EC50 of 79 mu M, but exhibited a far more less cytotoxicity (CC50 500 mu m). Other HPH derivatives showed no effects against antiviral activities and cytotoxicities. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.065