2-[2-(4-Fluorophenyl)ethynyl]-4-nitrophenol | 1447448-24-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-[2-(4-Fluorophenyl)ethynyl]-4-nitrophenol
• 英文别名: 2-[2-(4-fluorophenyl)ethynyl]-4-nitrophenol
• CAS: 1447448-24-9
• 化学式: C₁₄H₈FNO₃
• 分子量: 257.221
• InChiKey: OOIUZOGTJPYDEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[2-(4-Fluorophenyl)ethynyl]-4-nitrophenol 在 1-butyl-3-methylimidazolium hydroxide 作用下， 反应 2.5h， 以97%的产率得到2-(4-fluorophenyl)-5-nitro-1-benzofuran
  参考文献：
  名称：

  Recyclable [bmIm]OH promoted one-pot heterocyclization: synthesis of substituted benzofurans

  摘要：

  A single step access to polysubstituted benzo[b]furans has been achieved under simple and eco-compatible conditions. The heterocyclization proceeded efficiently. [bmIm]OH played a triple role as a solvent, base as well as catalyst. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.05.150

文献信息

• Recyclable [bmIm]OH promoted one-pot heterocyclization: synthesis of substituted benzofurans
  作者：I.R. Siddiqui、Malik Abdul Waseem、Shayna Shamim、Shireen、Arjita Srivastava、Anjali Srivastava

  DOI：10.1016/j.tetlet.2013.05.150

  日期：2013.8

  A single step access to polysubstituted benzo[b]furans has been achieved under simple and eco-compatible conditions. The heterocyclization proceeded efficiently. [bmIm]OH played a triple role as a solvent, base as well as catalyst. (C) 2013 Elsevier Ltd. All rights reserved.