5-chloro-3-phenyl-2,4(1H,3H)-quinazolinedione | 1449294-71-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-chloro-3-phenyl-2,4(1H,3H)-quinazolinedione
• 英文别名: 5-chloro-3-phenyl-1H-quinazoline-2,4-dione
• CAS: 1449294-71-6
• 化学式: C₁₄H₉ClN₂O₂
• 分子量: 272.691
• InChiKey: PJOONWGESZWGIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 0.5h， 生成 5-chloro-3-phenyl-2,4(1H,3H)-quinazolinedione
  参考文献：
  名称：

  Specific Inhibitors of Puromycin-Sensitive Aminopeptidase with a 3-(Halogenated Phenyl)-2,4(1H,3H)-quinazolinedione Skeleton

  摘要：

  Specific puromycin-sensitive aminopeptidase (PSA) inhibitors with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton were prepared and their structure-activity relationships were investigated. The nature (F, Cl or Br), number and position(s) of the halogen atom(s) introduced into the 3-phenyl group were concluded to be critical determinants of the inhibitory activity.

  DOI：

  10.3987/com-12-s(n)109

文献信息

• Specific Inhibitors of Puromycin-Sensitive Aminopeptidase with a 3-(Halogenated Phenyl)-2,4(1H,3H)-quinazolinedione Skeleton
  作者：Yuichi Hashimoto、Yotaro Matsumoto、Tomomi Noguchi-Yachide、Masaharu Nakamura、Yusuke Mita、Akiyoshi Numadate

  DOI：10.3987/com-12-s(n)109

  日期：——

  Specific puromycin-sensitive aminopeptidase (PSA) inhibitors with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton were prepared and their structure-activity relationships were investigated. The nature (F, Cl or Br), number and position(s) of the halogen atom(s) introduced into the 3-phenyl group were concluded to be critical determinants of the inhibitory activity.